Results 61 to 70 of about 4,419,614 (353)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Duplication errors due to brand name confusion; It is not always the name—Short case series

open access: yesClinical Case Reports, 2023
Key Clinical Message Confusion of drug names has been identified as a leading cause of medication errors and potential iatrogenic harm. Most of these errors occur because of look‐alike or sound‐alike drugs.
N. Mamunuwa   +9 more
doaj   +1 more source

MEDICATION ERRORS IN OUTPATIENTS OF A GOVERNMENT HOSPITAL IN YOGYAKARTA INDONESIA [PDF]

open access: yes, 2010
Background. Medication errors are important problems in hospitalized patients. Medication errors are inevitable and are affected by human factors. Nevertheless, the epidemiological data about medication errors in outpatients in Indonesia is still limited.
Abror, Jamiul   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Safety climate, nursing organizational culture and the intention to report medication errors: A cross-sectional study of hospital nurses

open access: yesNursing Practice Today, 2021
Background & Aim: Medication errors are the second most common accident after the fall accident in hospitals. Medication errors are a threat to patient safety. It is important to find the cause of such errors so that we can reduce them. However, the rate
Hyun Young Lee, Eun-Kyung Lee
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Effects of stratified medication review in high-risk patients at admission to hospital: a randomised controlled trial

open access: yesTherapeutic Advances in Drug Safety, 2020
Background: Patients at high risk of medication errors will potentially benefit most from medication reviews. An algorithm, MERIS, can identify the patients who are at highest risk of medication errors. The aim of this study was to examine the effects of
Dorthe Krogsgaard Bonnerup   +7 more
doaj   +1 more source

Why do nursing students make medication errors? A qualitative study in Indonesia

open access: yesJournal of Taibah University Medical Sciences, 2019
Objectives This study aimed to explore Indonesian nursing students' perceptions of the types and causes of medication errors in clinical rotations. Methods This descriptive qualitative study was conducted with 26 nursing students who had completed their ...
Lisa Musharyanti   +3 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Patient safety in Europe: medication errors and hospital-acquired infections [PDF]

open access: yes, 2008
The Report was commissioned by the European Federation of Nurses Associations (EFN) in November 2007 in order to support its policy statements on Patient Safety (June 2004).
Burke, J.   +3 more
core   +1 more source

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