Results 141 to 150 of about 11,907,481 (308)
Frontiers in PsychiatryIntroductionIn 2021, a computerized physician order entry (CPOE) system with an integrated clinical decision support system (CDSS) was implemented at a tertiary care center for the treatment of mental health conditions in Lübeck, Germany.
Katharina Wien +5 more
doaj +1 more source
Reviewing the Record: Medical Record Reviews for Medical Toxicology Research [PDF]
Journal of Medical Toxicology, 2018 Jaiva, Larsen +2 more
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Aging MedicineObjectives The increase in polypharmacy among older adults increases the risk of drug‐related problems, making multidisciplinary interventions essential.
Victoria Roncal‐Belzunce +9 more
doaj +1 more source
Implementation and impact analysis of a clinical pharmacy ambulatory: a two-year experience
Frontiers in PharmacologyIntroductionClinical pharmacy services contribute to safer and more effective medication use, yet remain underdeveloped in several countries, including Italy, due to limited recognition and funding.
Daniele Mengato +12 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
GMS Journal for Medical EducationAim: Interprofessional competencies should be taught, over and above undergraduate education, in post-graduate continuing education. For better collaboration between the fields of medicine and pharmacy in regard to the safety of drug therapy in cases of ...
Sabine Gehrke-Beck +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source