Results 171 to 180 of about 15,314,245 (299)

Structured medication review in elderly patients with chronic kidney disease to assess treatment appropriateness. [PDF]

Front Pharmacol
Navarro-Aznárez G, Navarro-Aznárez H, García-Ruiz MT, Galino-Serrano L, Díaz-Royo R, Balongo-Gutiérrez A, Berges-Mata P, Méndez-López F, Sánchez-Calavera MA.   +8 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Hospital-initiated community pharmacist medication review post-discharge. [PDF]

Aging Clin Exp Res
Clarkson L, Pollard B, Ng SK, Finn E, Lam AK, Khoo TK.   +5 more
europepmc   +1 more source

Evaluation of the antipsychotic medication review process at four long-term facilities in Alberta

, 2016
Arden Birney,1 Paola Charland,1 Mollie Cole,2 Mubashir Aslam Arain1 1Workforce Research & Evaluation, 2Seniors Health Strategic Clinical Network, Alberta Health Services, Calgary, AB, Canada Purpose: The goal of this evaluation was to understand how ...
Cole M, Charland P, Aslam Arain M, Birney A   +3 more
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Appropriateness over Numbers: Pharmacological Burden and Scalable Medication Review in Older Adults. [PDF]

Geriatrics (Basel)
Pstrągowski M, Hachlica D, Izbicki Ł.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer co-medication quality in older patients with polypharmacy: A large randomized trial testing a medication review versus usual care. [PDF]

J Intern Med
Degen M, Kopp-Schneider A, Vlaski T, Carlsson S, Hallermann P, Jewlanowa L, Barinoff J, Goede V, Lüders C, Kiefer-Trendelenburg T, Lüftner D, Doll J, Wagner J, Leibbrand B, Brenner H, Schöttker B.   +15 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Narrative Review of Medication Optimisation in Older Adults with Polypharmacy: From Structured Medication Review to AI-Enabled Medication Safety. [PDF]

Healthcare (Basel)
Aro R, Wojszel ZB, Duez P, Lecron F, Patris S.   +4 more
europepmc   +1 more source