Results 91 to 100 of about 890,148 (262)

Reviewing the Record: Medical Record Reviews for Medical Toxicology Research [PDF]

Journal of Medical Toxicology, 2018
Jaiva, Larsen, Mark B, Mycyk, Trevonne M, Thompson   +2 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Developing Quality Indicators for the Pharmacological Management of Chronic Non-Cancer Pain in Older Adult Inpatients: A RAND/UCLA Delphi Study

Journal of Pain Research
Aljoscha Noël Goetschi,1,2 Nicole Schönenberger,1,2 Ursina Wernli,1,2 Carla Meyer-Massetti1,3 1Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Bern University Hospital, Bern, Bern, Switzerland; 2Graduate School for Health ...
Goetschi AN, Schönenberger N, Wernli U, Meyer-Massetti C   +3 more
doaj  

Influence of Potentially Inappropriate Medication Use on Older Australians’ Admission to Emergency Department Short Stay

Geriatrics
Older people in the emergency department (ED) often pose complex medical challenges, with a significant prevalence of polypharmacy and potentially inappropriate medicines (PIMs) in Australia. A retrospective analysis of 200 consecutive patients aged over
Hoa T. M. Tran, Cristina Roman, Gary Yip, Michael Dooley, Mohammed S. Salahudeen, Biswadev Mitra   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reduced prevalence of drug-related problems in psychiatric inpatients after implementation of a pharmacist-supported computerized physician order entry system - a retrospective cohort study

Frontiers in Psychiatry
IntroductionIn 2021, a computerized physician order entry (CPOE) system with an integrated clinical decision support system (CDSS) was implemented at a tertiary care center for the treatment of mental health conditions in Lübeck, Germany.
Katharina Wien, Julia Thern, Anika Neubert, Britta-Lena Matthiessen, Stefan Borgwardt, Stefan Borgwardt   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Impact of a Multidisciplinary Approach to Polypharmacy Management in Community‐Dwelling Older Adults: Insights From a Specialized Outpatient Clinic

Aging Medicine
Objectives The increase in polypharmacy among older adults increases the risk of drug‐related problems, making multidisciplinary interventions essential.
Victoria Roncal‐Belzunce, Marta Gutiérrez‐Valencia, Bernardo Abel Cedeño‐Veloz, Ramón San Miguel, Itxaso Marín‐Epelde, Arkaitz Galbete, Javier Preciado Goldaracena, María Irache Ezpeleta, Karmele Garaioa‐Aramburu, Nicolás Martínez‐Velilla   +9 more
doaj   +1 more source

Teaching interprofessional competency in graduate education and training – implementation and evaluation of a case-based, interprofessional online seminar for pharmacists and physicians specializing in general practice

GMS Journal for Medical Education
Aim: Interprofessional competencies should be taught, over and above undergraduate education, in post-graduate continuing education. For better collaboration between the fields of medicine and pharmacy in regard to the safety of drug therapy in cases of ...
Sabine Gehrke-Beck, Nicole Zimmermann, Stefan Wind, Ulrike Sonntag   +3 more
doaj   +1 more source