Results 121 to 130 of about 1,399,010 (340)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Design research on a smart infusion device to reduce medical workload and enhance patient safety

Scientific Reports
In traditional infusion processes, issues such as untimely medication replacement and patients’ difficulty in continuously monitoring their medication levels are prevalent.
Bo Mu, Yilun Wang, Xunchen Liu, Mohammad Puad Bebit, Mingzhang Chen, Hailin Wu, Wei Zhang, Lanxin Wang, Yuan Fang, Kang Dong   +9 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Medication use and knowledge in a sample of Indigenous and non‐Indigenous prisoners

Australian and New Zealand Journal of Public Health, 2014
Objective: To (a) characterise medication use and knowledge, according to Indigenous status, and (b) identify independent correlates of medication knowledge in a sample of adult prisoners.
Megan Carroll, Stuart A. Kinner, Edward B. Heffernan   +2 more
doaj   +1 more source

Technical Considerations for Successful Implementation of a Barcode-based Medication System in Hospital [PDF]

, 2009
Jong Soo Choi, Dongsoo Kim
openalex   +1 more source

Adverse events related to herbal dietary supplements and over-the-counter medications containing laxatives: a 10-year update from the Italian Phytovigilance and Pharmacovigilance systems.

, 2022
Niccolò Lombardi, Giada Crescioli, Valentina Maggini, Valentina Brilli, Francesca Menniti‐Ippolito, Ilaria Ippoliti, Simona Potenza, Francesca Renda, Gabriela Mazzanti, Annabella Vitalone, Alfredo Vannacci, Fabio Firenzuoli   +11 more
openalex   +2 more sources

Providers’ Perception of Alert Fatigue After Implementation of User-Filtered Warnings [PDF]

, 2019
Alert fatigue is a complex problem that many health institutions face when using an electronic health record (EHR). The addition of user-filtered warnings (UFW) is a physicians’ proposed intervention at Inova Health System (IHS), a large 5-hospital ...
Afaq, Hina, Escano, Alisa K, Dr., Lear, Rebecca, Dr., Mukundan, Sahaana, Washington, Casey, Dr., Zia, Sadaf   +5 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Detecting Adverse Drug Events Through the Chronological Relationship Between the Medication Period and the Presence of Adverse Reactions From Electronic Medical Record Systems: Observational Study

, 2021
Kei Teramoto, Toshihiro Takeda, Naoki Mihara, Yoshie Shimai, Shiro Manabe, Shigeki Kuwata, Hiroshi Kondoh, Yasushi Matsumura   +7 more
openalex   +1 more source