Results 191 to 200 of about 1,399,010 (340)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Closed-loop medication safety management reduces inappropriate medication in elderly patients with rheumatic and immunologic diseases. [PDF]

Medicine (Baltimore)
Chen D, Feng J, Chen Z, Chen M.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Health technology assessment of an automated unit-dose drug distribution system in a high-specialization national referral hospital of the Italian National Health Service. [PDF]

Glob Reg Health Technol Assess
Croce D, De Nardo F, Convenga F, Mueller D, Franzin M.   +4 more
europepmc   +1 more source

A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence [PDF]

, 2016
Mohamed El Alili, Bernard Vrijens, Jenny Demonceau, Silvia Evers, Mickaël Hiligsmann   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Linking FHIR-Based Medication Data to a Computable Algorithm for Heart Medication Optimization: A Critical Component of Any Medication Learning Health System. [PDF]

Learn Health Syst
LeGrand J, Ali MS, Flynn A, Arzac J, Lester C, Dorsch MP.   +5 more
europepmc   +1 more source

The prevalence and causes of self‐medication among medical university students in Iran during COVID‐19 outbreak and its implications for public health and health systems: A cross‐sectional study [PDF]

Fatemeh Kokabisaghi, Mina Sadat Mousavi Emadi, A. Jamil Tajik, Farshad Sharifi, Elaheh Houshmand, Mehdi Varmaghani   +5 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Automating Individualized Notification of Drug Recalls to Patients: Complex Challenges and Qualitative Evaluation. [PDF]

JMIRx Med
Gadgil M, Pavlakos R, Carini S, Turner B, Elder I, Hess W, Houle L, Huff L, Johanson E, Ramos-Izquierdo C, Liang D, Ogonowski P, Phipps J, Peryea T, Sim I.   +14 more
europepmc   +1 more source