Results 211 to 220 of about 1,373,920 (341)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Knowledge, attitudes, practices towards medication errors and adverse drug reactions reporting among healthcare professionals in Dongola, Sudan: a cross-sectional study. [PDF]

Sci Rep
Issak MA, Mohamed ZFA, Mohammed KAA.
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Reply to Borrás-Blasco <i>et al.</i>: How Adherence Shapes Persistence in IPF Treatment: A Call for Real-World Insight. [PDF]

Ann Am Thorac Soc
Kulkarni T, Flaherty K, Gupta S, Tu YH, Case AH.   +4 more
europepmc   +1 more source

The Effect of Simulation Integrated with Problem Based Learning on System Thinking, Learning Flow, Proactivity in Problem Solving and Performance Ability for Medication in Nursing Students [PDF]

, 2018
Minjeong Park, Dongwon Choi
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Using Medication Pass Analysis to Examine Longitudinal Changes in VA Inpatient Nurse Staffing and Workload Before and Through the COVID-19 Pandemic: 2019-2022. [PDF]

Med Care
Knox MK, Eck CS, Dorsey L, Mehta PD, Yang C, Petersen LA.   +5 more
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Digital medicine, intelligent medicine, and smart medication system.

Indian J Pharmacol
Rajaram S, Gupta S, Medhi B.
europepmc   +1 more source

"You can do this at home and people won't find out": a qualitative exploration of women's experiences with the use of medication abortion drugs received directly from pharmacies in Nepal. [PDF]

BMC Public Health
Rijal N, Rai SS, Shrestha H, Foster AM.
europepmc   +1 more source