Results 81 to 90 of about 544,887 (244)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Medication information completeness in discharge summaries from a Norwegian rural hospital – a cross-sectional study

BMC Health Services Research
Background Hospital discharge summaries are crucial for transferring patient information to subsequent care providers, yet they often contain incomplete and incorrect medication details.
Beate Hennie Garcia, Michelle Thao Nguyen, Lars Småbrekke, Frode Skjold, Trine Aag   +4 more
doaj   +1 more source

Activity Theory Analysis of Heart Failure Self-Care [PDF]

, 2017
The management of chronic health conditions such as heart failure is a complex process emerging from the activity of a network of individuals and artifacts.
Cornet, Victor, Holden, Richard J., Voida, Stephen   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Life, Life Support, and Death Principles, Guidelines, Policies and Procedures for Making Decisions That Respect Life [PDF]

, 1997
The following is the third edition of a booklet by the American Life League, Inc. The section on Ordinary/Extraordinary Means has been revised.
Byrne, Paul A., Colliton, William F., Evers, Joseph C., Fangman, Timothy R., Kramper, Ralph J., L\u27Ecuyer, Jerome, Nilges, Richard G., Sadick, Mary H., Shen, Jerome T.Y., Simon, Frank G.   +9 more
core   +1 more source

Quality of medication use in primary care - mapping the problem, working to a solution: a systematic review of the literature [PDF]

, 2009
Background: The UK, USA and the World Health Organization have identified improved patient safety in healthcare as a priority. Medication error has been identified as one of the most frequent forms of medical error and is associated with significant ...
A Hassey, A Manday, AG Zermansky, Alan Willson, B Dean Franklin, B Gethins, BD Franklin, BD Franklin, C Duggan, C Duggan, Department of Health, Department of Health, Department of Health, Department of Health, DJ Collins, DM Berwick, Esimai, I Jones, Institute of Healthcare Improvement, Institute of Medicine, J Bicheno, JC Benneyan, JH Hippisley-Cox, K Brookes, K Jordon, L Pickrell, L Smith, Lina Eliasson, M Pirohamed, M Rother, M Sagripanti, MP Tully, MT Taner, N Barber, N Proudlove, N Slack, National Collaborating Centre for Primary Care, National Institute of Clinical Excellence, Nick Barber, P Donyai, Paul Walley, PHG Beardon, R Natarajan, RL Howard, S Ahmed, S Morcos, S Olsen, S Rees, S Royal, S Spear, Sara Garfield, SNH Shah, WMS Al-Shaqha, World Health Organization, YH Jani   +54 more
core   +4 more sources

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Redesigning the 'choice architecture' of hospital prescription charts: a mixed methods study incorporating in situ simulation testing. [PDF]

, 2014
Objectives: To incorporate behavioural insights into the user-centred design of an inpatient prescription chart (Imperial Drug Chart Evaluation and Adoption Study, IDEAS chart) and to determine whether changes in the content and design of prescription ...
Bicknell, C, Charani, E, Darzi, A, Franklin, BD, Gilchrist, M, Jabbar, A, King, D, Miller, G, Vlaev, I, Wu, Z   +9 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source