Results 161 to 170 of about 548,348 (332)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Physicians' Practice of Dispensing Medicines: A Qualitative Study [PDF]

, 2014
Objectives: The physical act of giving medication to patients to administer away from a health care setting, dispensing, is normally performed by pharmacists. Dispensing of medication by physicians is a neglected patient safety issue, and having observed
Baker, Paul, Bates, Damien, Darbyshire, Daniel, Gordon, Morris   +3 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Investigation of the Causes of Medication Errors and Not Reporting it in Nurses of the Shahid Beheshti Hospital of Qom City, 2017, (Iran)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Medication errors can cause serious problems in health systems and is considered as a threat for patient safety. The purpose of this study was to investigate the types and causes of medication errors as well as their non ...
Alireza Amiri Mehra, Leila Ghanbari Afra, Sareh Ebrahim Kuchak, Zahra Farghadani, Zahra Aliakbarzadeh Arani   +4 more
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Introducing Unit Dose Dispensing in a University Hospital – Effects on Medication Safety and Dispensing Time

Risk Management and Healthcare Policy
Hanne Katriina Ahtiainen,1,2 Carita Lindén-Lahti,1,2 Susanna Heininen,1 Anna-Riia Holmström,1 Lotta Schepel2,3 1Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2HUS Pharmacy, Helsinki University Hospital, Helsinki, Finland; 3Quality and ...
Ahtiainen HK, Lindén-Lahti C, Heininen S, Holmström AR, Schepel L   +4 more
doaj  

The Medical Record System at Okhaldhunga Community Hospital in Rural Nepal

, 2011
Background Okhaldhunga Community Hospital (OCH) lies in a rural area in the east of Nepal. In this area there is no reliable power supply so it is still not possible for this hospital to use a computer based medical record system (MRS) like we do in most western hospitals today.
Skretting, Åge Aleksander, Saxe, Daniel Stenberg   +1 more
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Norman Regional Health System: A City-Owned Public Trust Dedicated to Improving Performance [PDF]

, 2010
Describes successful strategies for providing recommended treatment on process-of-care measures, including board and administration support, order sets, concurrent review, performance feedback, transparency, and engaging nurses.
Sharon Silow-Carroll
core