Sex differences in the pituitary TGFβ1 system: the role of TGFβ1 in prolactinoma development [PDF]
, 2019 Prolactinomas are the most frequent functioning pituitary adenomas, and sex differences in tumor size, behavior and incidence have been described. These differences have been associated with earlier diagnosis in woman, as well as with serum estradiol ...
Abeledo Machado, Alejandra Inés +6 more
core +1 more source
Consequences of the Lack of IL-10 in Different Endotoxin Effects and its Relationship With Glucocorticoids [PDF]
, 2019 Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a ...
Barrientos, Gabriela Laura +10 more
core +1 more source
Restoring Conjunctival Tolerance by Topical Nuclear Factor–κB Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice [PDF]
, 2014 Purpose.: To evaluate the role of nuclear factor–κB (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis.
Gabelloni, María Laura +6 more
core +1 more source
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]
, 2019 We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina +9 more
core +1 more source
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor [PDF]
, 2019 Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed.
Abramovich, Dalhia Nurit +7 more
core +1 more source
Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]
, 2016 Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol +6 more
core +2 more sources
Millenium, 2021 Introdução: O excesso de peso (EP) apresenta-se como um problema de saúde pública. Contudo os profissionais da saúde ainda não estão preparados para uma atuação adequada.
Maria Magaly Medeiros +2 more
doaj +1 more source
El pédulo maniqueo de la investigación clínica en Costa Rica.
Diálogos, 2011 El artículo aborda el espinoso tema de la investigación clínica en sujetos humanos en Costa Rica. La investigación explora las relaciones entre las compañías transnacionales y la práctica médica nacional. Las compañías determinan sus condiciones, fines y
Luis Fallas López
doaj +3 more sources
EL DUALISMO CARTESIANO Y SU RELACIÓN CON LA NUEVA MEDICINA A LA LUZ DE SU CORRESPONDENCIA [PDF]
KriterionRESUMEN A pesar de que la reducción de R. Descartes de los animales a meras máquinas puede explicarse como una consecuencia lógica de su punto de partida metafísico y gnoseológico, se puede argüir que esta reducción parece muy difícil de defender, puesto
Alejandro Rojas Jiménez +1 more
doaj +2 more sources
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins [PDF]
, 2017 The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines ...
Abba, Martín Carlos +7 more
core +3 more sources