Results 41 to 50 of about 1,752,513 (362)

A medicina preventiva

Revista Portuguesa de Clínica Geral, 2008
Introdução: Segundo a Carta de Ottawa (OMS, 1986) a Promoção da Saúde consiste no processo que visa criar condições para que as pessoas aumentem a sua capacidade de controlar os factores determinantes da saúde, no sentido de a melhorar. A Prevenção é uma das principais componentes da promoção da saúde.
Carlos Martins, Alberto Hespanhol, Luciana Couto   +2 more
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from chronic lymphocytic leukemia patients by human macrophages [PDF]

, 2015
We have read with great interest the recent article of Kohrt, H.E. et al1 showing that Ibrutinib prevented NK cell mediated cytotoxicity of antibody-coated CLL cells in vitro.
Almejún, María Belén, Bezares, Raimundo F., Borge, Mercedes, Cabrejo, María, Colado, Ana, Fernández Grecco, Horacio, Gamberale, Romina, Giordano, Mirta Nilda, Podaza, Enrique Arturo   +8 more
core   +2 more sources

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources

Derechos humanos y bioética en medicina: por una medicina como bien común

Revista Iberoamericana de Bioética
La brecha de inequidad en cuidados de salud y atención médica va en constante aumento, sin que los derechos humanos —derecho a la salud— ni la globalizante bioética logren mitigarla o sensibilizar sobre sus consecuencias deletéreas. Este texto reflexiona
Miguel Kottow Lang
doaj   +1 more source

Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines [PDF]

, 2019
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Bollani, Sabrina Natalia, Cabilla, Jimena Paula, Cordeiro, Georgina, Duvilanski, Beatriz Haydee, Pino, María Teresa Luján, Ricci, Analía Gabriela, Ronchetti, Sonia Alejandra   +6 more
core   +1 more source

Medicina darwiniana

Acta Médica Costarricense, 2009
En 2009 se celebran 200 años del nacimiento de Charles Darwin y 150 años de la publicación de su libro El origen de las especies; es pregunta obligada por qué lo hizo a 50 años de edad, cuando aparentemente contaba con los elementos para hacerlo muchos años antes. De hecho, aunque no era inminente, existía el riesgo razonable de que se le adelantara en
openaire   +5 more sources

Epileptic events in the XIX century as reported by the Brazilian Royal Family Eventos epilépticos no século XIX segundo relatos da Família Real Brasileira

Arquivos de Neuro-Psiquiatria, 2010
Members of the Brazilian Royal Family carry a rich medical history of epileptic seizures and alike. OBJECTIVE: To present the medical knowledge about epilepsy by the time of the Brazilian Empire, as reported by the royal family.
Marleide da Mota Gomes, Heber de Souza Maia-Filho   +1 more
doaj   +1 more source

Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice [PDF]

, 2014
Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality.
Cotignola, Javier Hernan, de Luca, Paola, de Siervi, Adriana, Gardner, Kevin, Mazza, Osvaldo, Meissl, Roberto Jose, Moiola, Cristian Pablo, Pignataro, Omar Pedro, Rodríguez Seguí, Santiago Andrés, Vallecorsa, Pablo Daniel, Vazquez, Elba Susana, Zalazar, Florencia   +11 more
core   +1 more source

Medicina

Revista Ciencia y Salud Integrando Conocimientos, 2017
La Facultad de Medicina y Cirugía de la UCIMED, está desarrollando estrategias educativas ya probadas en el mundo, con el fin de dar el salto educativo post Flexneriano que requiere el país, disminuyendo el atraso educativo. Se estima en unos 30 - 40 años, lo que significa, que lo que hoy realizamos en nuestro país en materia educativa, ya fue ...
openaire   +3 more sources