Results 71 to 80 of about 1,955,095 (348)
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice [PDF]
, 2014 Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality.
Cotignola, Javier Hernan +11 more
core +1 more source
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Botánica médica de los indígenas Cuna de Arquía, Chocó
Caldasia, 1995 A medical-botanical study in the indigenous Cuna community of Arquia (Choco) with the collaboration of the Inatuledi (botanical doctor) Claudio Izquierdo is presented. Different aspects about health, illness and the healing process are discussed.
Giraldo Tafur Clara
doaj
História, Ciências, Saúde: Manguinhos, 2007 Apresenta alguns resultados do estudo sobre as práticas de médicos e farmacêuticos na cidade de São Pedro de Uberabinha (MG), hoje Uberlândia, durante as décadas de 1890 e 1920.
Antônio de Pádua Bosi
doaj +1 more source
Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. [PDF]
, 2005 Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells.
Ascione, Barbara +7 more
core +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
História, Ciências, Saúde: Manguinhos, 2007 Os avanços da medicina no conhecimento do corpo humano e nas formas de tratar as enfermidades não tiveram impacto somente sobre o corpo individual. A partir do século das luzes a medicina passou a se preocupar cada vez mais com a 'saúde dos povos'.
Jean Luiz Neves Abreu
doaj +1 more source
Chronic adult T-cell Leukemia in a young male after blood transfusion as a newborn [PDF]
, 2016 Human T-cell Lymphotropic virus type 1 (HTLV-1) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HTM/TSP).
Altube, Alejandra +10 more
core +2 more sources
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source