FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells [PDF]
Antioxidants, 2021 Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery.
Miguel Córdova-Delgado +7 more
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Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis [PDF]
Frontiers in Cell and Developmental Biology, 2021 The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood.
Félix A. Urra +11 more
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Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia [PDF]
Antioxidants, 2022 More than 80 million people live and work (in a chronic or intermittent form) above 2500 masl, and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 100,000 people work in high-altitude shifts, where stays in the ...
Alejandro González-Candia +7 more
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The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells [PDF]
Toxins, 2020 Since Rhinella sp. toads produce bioactive substances, some species have been used in traditional medicine and magical practices by ancient cultures in Peru.
Guillermo Schmeda-Hirschmann +8 more
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An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells [PDF]
Frontiers in Oncology, 2022 Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies.
Félix A. Urra +9 more
doaj +2 more sources
Expression Levels of Inflammatory and Oxidative Stress-Related Genes in Skin Biopsies and Their Association with Pityriasis Alba [PDF]
Medicina, 2020 Background and objectives: Pytiriasis alba (PA) is a common skin disorder which affects 80% of children between six and 16 years. The etiology of PA is unclear, but hypo-pigmented patches in photo-exposed zones characterize the disease.
Margarita L. Martinez-Fierro +8 more
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Moderate Exercise in Spontaneously Hypertensive Rats Is Unable to Activate the Expression of Genes Linked to Mitochondrial Dynamics and Biogenesis in Cardiomyocytes [PDF]
Frontiers in Endocrinology, 2020 Hypertension (HTN) is a public health concern and a major preventable cause of cardiovascular disease (CVD). When uncontrolled, HTN may lead to adverse cardiac remodeling, left ventricular hypertrophy, and ultimately, heart failure.
Clara Quiroga +13 more
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Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors [PDF]
Scientific ReportsAutophagy is a natural process in which the cell degrades substances through the lysosomal pathway. One of the most studied mechanisms for regulating autophagy is the mTOR signaling pathway.
José Miguel Alcaíno +6 more
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Endosymbiosis in trypanosomatids: the bacterium regulates the intermediate and oxidative metabolism of the host cell [PDF]
mSphereEndosymbiosis in trypanosomatids involves a mutualistic association between a symbiotic bacterium and a host protozoan and represents an excellent model for studying metabolic coevolution and the origin of organelles. This work investigated the influence
Azuil Barrinha +7 more
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Dr. Raúl Felipe Señor García: un científico ejemplar
Medimay, 2019 Se presenta la vida y obra del Dr. Raúl Felipe Señor García,Doctor en Medicina, promotor y protagonista de la labor docente asistencial en el municipio de Madruga; quien fuera abanderado y ejemplo por su destacado trabajo en el movimiento del desarrollo ...
Haydeé Mabel Llanes Torres +1 more
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