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Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome

Intensive Care Medicine Experimental
Introduction Acute respiratory distress syndrome (ARDS) is a severe condition with high morbidity and mortality, characterized by significant clinical heterogeneity.
Gabriela Meza-Fuentes +5 more
doaj +1 more source

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Three clinical staging models for bipolar disorder (BD) have been published, each with a different but complementary approach and focus. The International Society for Bipolar Disorders Staging Task Force aimed to integrate these models into one comprehensive three‐dimensional staging model, separately rating bipolar spectrum ...
Ralph Kupka +27 more
wiley +1 more source

Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Lithium is recommended as the first‐line maintenance treatment for older adults with bipolar disorder (OABD). However, age‐related reduction in renal clearance, heightened sensitivity to adverse effects, and drug interactions increase the risk of toxicity and necessitate lower therapeutic serum levels in this population.
Paula V. Nunes +15 more
wiley +1 more source

Desarrollo de un ensayo casero para la detección de IgG contra el core del virus de la Hepatitis B

Avances en Biomedicina, 2016
Hepatitis B infection affects individuals worldwide, especially in Latin America. Serological assay for HBV antibodies and antigen detection, are critical for HBV diagnostic and treatment.
Yismelvy Márquez-Toro +11 more
doaj

Clinical Characterization of Patients With 5q Spinal Muscular Atrophy Types 2 and 3 in Brazil: A Cross‐Sectional Observational Study

Clinical Genetics, Volume 110, Issue 2, Page 172-188, August 2026.
This study describes the clinical heterogeneity of Brazilian patients with 5q spinal muscular atrophy types 2 and 3, highlighting prolonged diagnostic delays and the impact of disease duration on motor function. Early genetic diagnosis and access to multidisciplinary care are crucial to preserve functional outcomes.
Elice Carneiro Batista +31 more
wiley +1 more source

Genetic Landscape of Hearing Loss in Brazilian Patients Reveals Population‐Specific Variants and Clinical Correlations

Clinical Genetics, Volume 110, Issue 2, Page 210-226, August 2026.
The Burden: Hearing loss (HL) is the most prevalent sensory disorder globally, affecting 1.5 million individuals in Brazil. The Gap: While > 150 genes are linked to HL, the genetic architecture in underrepresented populations like Brazil is poorly defined. The Problem: This lack of data limits diagnostic yield and the application of precision medicine.
Stella Diogo‐Cavassana +7 more
wiley +1 more source

Freezing of Gait: A Tribute to Nir Giladi

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
The figure shows the location of the selected regions in sagittal, coronal, and axial views of a structural brain image. PD: putamen (blue), thalamus (green), DLPFC (red), frontopolar (yellow). PD + FoG: pallidum (pink), nucleus accumbens (blue/pink), frontopolar (yellow), thalamic (green), DLPFC (red), anterior midcingulate volumes (blue), and SMA ...
Luana dos Santos de Oliveira +6 more
wiley +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

HIV Medicine, Volume 27, Issue 8, Page 1312-1332, August 2026.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria +555 more
wiley +1 more source

Prognostic Impact of Concomitant Genomic Alterations in FGFR2‐Positive Cholangiocarcinoma Treated With Pemigatinib

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background & Aims Anti‐FGFR therapies changed the treatment landscape for patients with previously treated, advanced, or metastatic cholangiocarcinoma (CCA) harbouring FGFR2 fusions/rearrangements. However, primary resistance to FGFR inhibitors remains a key challenge. In the present real‐world study, we aimed to evaluate the prognostic impact
Carolina Liguori +45 more
wiley +1 more source

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Carnosine‐related metabolism in rat cardiomyocytes and human heart tissue. Jade V Creighton, Lívia de Souza Gonçalves, Saulo Gil, Bianca Scigliano Vargas, Leonardo Jensen, Marisa Helena Gennari de Medeiros, Hamilton Roschel, Mark D Turner, Craig L Doig, Guilherme Giannini Artioli, Craig Sale.
Jade V. Creighton +10 more
wiley +1 more source

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