Results 11 to 20 of about 141,552 (230)

Ansiedade e depressão durante o estado de emergência nacional por COVID-19: realidade numa Unidade de Saúde Familiar

open access: yesRevista Portuguesa de Medicina Geral e Familiar, 2021
Objetivos: Passaram alguns meses desde que foi confirmado o primeiro caso da doença COVID-19 em Portugal. A rápida progressão desta pandemia levou a diversas alterações no quotidiano dos utentes da Unidade de Saúde Familiar (USF) Santiago de Leiria ...
Marta Marques Santana   +6 more
doaj   +1 more source

Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors

open access: yesAdvanced Science, Volume 10, Issue 25, September 5, 2023., 2023
Remodeling of a tumor immunosuppressive microenvironment via a polyoxazoline‐poly(lactic‐co‐glycolic) acid nanovaccine combined with modulators of αCSF‐1R and αPD‐1 controls tumor growth and prolongs survival of three murine solid tumor models (CT26, MC38, and B16F10), thus constituting a promising approach to improve cancer immunotherapy.
Ana I. Matos   +19 more
wiley   +1 more source

Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report

open access: yesAllergy, Volume 78, Issue 7, Page 1758-1776, July 2023., 2023
Abstract Biomarkers for the diagnosis, treatment and follow‐up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical ...
Jean Bousquet   +106 more
wiley   +1 more source

Investigação em medicina geral e familiar: tendências e vazios [PDF]

open access: yesRevista Portuguesa de Clínica Geral, 2020
Introdução e objetivo(s): A produção científica de uma especialidade é um sinal de vitalidade e de autorreflexão indispensável à identidade de qualquer disciplina científica. O estudo pretende descrever a investigação original efetuada por especialistas ou internos da especialidade de medicina geral e familiar (MGF) publicada na Acta Médica Portuguesa (
Joana Abreu   +3 more
openaire   +2 more sources

Ultrasound findings and prognosis of shoulder pain: A role for Doppler signal?

open access: yesJournal of Clinical Ultrasound, Volume 51, Issue 5, Page 837-844, June 2023., 2023
Tendinous Doppler signal might be a marker for a better prognosis of shoulder pain. Abstract Purpose To find ultrasound prognostic factors for shoulder pain. Methods This was an observational, prospective study, comparing the evolution of ultrasound findings with clinical outcomes, in patients with shoulder pain. Data were collected in two appointments,
João Janeiro   +5 more
wiley   +1 more source

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

open access: yesAllergy, Volume 78, Issue 5, Page 1169-1203, May 2023., 2023
Abstract Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept.
J. Bousquet   +249 more
wiley   +1 more source

Phenotype of BTK‐lacking myeloid cells during prolonged COVID‐19 and upon convalescent plasma

open access: yesEuropean Journal of Haematology, Volume 110, Issue 2, Page 209-212, February 2023., 2023
Abstract XLA patient with 7‐month course of COVID‐19 with persistent plasma SARS‐CoV‐2 load revealed a sustained non‐inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS‐COV‐2 infection.
André M. C. Gomes   +11 more
wiley   +1 more source

Tratamento da exacerbação da asma na criança com inaladores pressurizados de dose controlada e câmara expansora: Dose segura e eficaz de Salbutamol

open access: yesRevista Portuguesa de Medicina Geral e Familiar, 2013
Objectivos: Os agonistas ß 2 de curta duração são os fármacos de eleição no tratamento das exacerbações agudas de asma, sendo o salbutamol o mais frequentemente utilizado. No entanto, a dose recomendada é ainda controversa.
Alexandra Sousa   +3 more
doaj   +1 more source

Cadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma

open access: yesMolecular Oncology, Volume 16, Issue 14, Page 2611-2631, July 2022., 2022
Here, we identified Cadherin‐3 (CDH3) as a novel oncogene in glioblastoma (GBM). CDH3 affected distinct cancer hallmarks in vitro and was related to increased tumor growth and shorter survival in vivo. Clinically, CDH3 correlated with cancer‐related signatures and was overexpressed in a subset of patients with poor prognosis, thus suggesting that CDH3 ...
Eduarda P. Martins   +14 more
wiley   +1 more source

Quando a família é a principal doença

open access: yesRevista Portuguesa de Medicina Geral e Familiar, 2013
Introdução: O caso clínico relata os vários sinais de disfunção familiar detectados pelo médico de família, no decorrer das consultas, bem como alerta para a importância da contextualização holística do doente no âmbito dos Cuidados de Saúde Primários.
António Santos   +3 more
doaj   +1 more source

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