Results 11 to 20 of about 3,173 (188)
Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors
Advanced Science, Volume 10, Issue 25, September 5, 2023., 2023 Remodeling of a tumor immunosuppressive microenvironment via a polyoxazoline‐poly(lactic‐co‐glycolic) acid nanovaccine combined with modulators of αCSF‐1R and αPD‐1 controls tumor growth and prolongs survival of three murine solid tumor models (CT26, MC38, and B16F10), thus constituting a promising approach to improve cancer immunotherapy.Ana I. Matos, Carina Peres, Barbara Carreira, Liane I. F. Moura, Rita C. Acúrcio, Theresa Vogel, Erik Wegener, Filipa Ribeiro, Marta B. Afonso, Fábio M. F. Santos, Águeda Martínez‐Barriocanal, Diego Arango, Ana S. Viana, Pedro M. P. Góis, Liana C. Silva, Cecília M. P. Rodrigues, Luis Graca, Rainer Jordan, Ronit Satchi‐Fainaro, Helena F. Florindo +19 morewiley +1 more sourcePatient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report
Allergy, Volume 78, Issue 7, Page 1758-1776, July 2023., 2023 Abstract
Biomarkers for the diagnosis, treatment and follow‐up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical ...Jean Bousquet, Mohamed H. Shamji, Josep M. Anto, Holger J. Schünemann, G. Walter Canonica, Marek Jutel, Stefano Del Giacco, Torsten Zuberbier, Oliver Pfaar, Joao A. Fonseca, Bernardo Sousa‐Pinto, Ludger Klimek, Wienczyslawa Czarlewski, Anna Bedbrook, Rita Amaral, Ignacio J. Ansotegui, Sinthia Bosnic‐Anticevich, Fulvio Braido, Claudia Chaves Loureiro, Bilun Gemicioglu, Tari Haahtela, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Paolo M. Matricardi, Frederico S. Regateiro, Boleslaw Samolinski, Mikhail Sofiev, Sanna Toppila‐Salmi, Arunas Valiulis, Maria Teresa Ventura, Cristina Barbara, Karl C. Bergmann, Michael Bewick, Hubert Blain, Matteo Bonini, Louis‐Philippe Boulet, Rodolphe Bourret, Guy Brusselle, Luisa Brussino, Roland Buhl, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Ivan Cherrez‐Ojeda, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephanie Dramburg, Wytske J. Fokkens, Maia Gotua, Enrico Heffler, Zhanat Ispayeva, Juan Carlos Ivancevich, Guy Joos, Igor Kaidashev, Helga Kraxner, Violeta Kvedariene, Désirée E. Larenas‐Linnemann, Daniel Laune, Olga Lourenço, Renaud Louis, Mika Makela, Michael Makris, Marcus Maurer, Erik Melén, Yann Micheli, Mario Morais‐Almeida, Joaquim Mullol, Marek Niedoszytko, Robyn O'Hehir, Yoshitaka Okamoto, Heidi Olze, Nikolaos G. Papadopoulos, Alberto Papi, Vincenzo Patella, Benoit Pétré, Nhân Pham‐Thi, Francesca Puggioni, Santiago Quirce, Nicolas Roche, Philip W. Rouadi, Ana Sá‐Sousa, Hironori Sagara, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Milan Sova, Charlotte Suppli Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Maria J. Torres, Ioanna Tsiligianni, Omar S. Usmani, Erkka Valovirta, Tuula Vasankari, Rafael José Vieira, Dana Wallace, Susan Waserman, Mihaela Zidarn, Arzu Yorgancioglu, Luo Zhang, Tomas Chivato, Markus Ollert +106 morewiley +1 more sourceUltrasound findings and prognosis of shoulder pain: A role for Doppler signal?
Journal of Clinical Ultrasound, Volume 51, Issue 5, Page 837-844, June 2023., 2023 Tendinous Doppler signal might be a marker for a better prognosis of shoulder pain. Abstract Purpose
To find ultrasound prognostic factors for shoulder pain. Methods
This was an observational, prospective study, comparing the evolution of ultrasound findings with clinical outcomes, in patients with shoulder pain. Data were collected in two appointments,João Janeiro, Sofia Barreira, Patrícia Martins, Marco Sarmento, Jorge Campos, João Eurico Fonseca +5 morewiley +1 more sourceRhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
Allergy, Volume 78, Issue 5, Page 1169-1203, May 2023., 2023 Abstract
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept.J. Bousquet, E. Melén, T. Haahtela, G. H. Koppelman, A. Togias, R. Valenta, C. A. Akdis, W. Czarlewski, M. Rothenberg, A. Valiulis, M. Wickman, M. Akdis, D. Aguilar, A. Bedbrook, C. Bindslev‐Jensen, S. Bosnic‐Anticevich, L. P. Boulet, C. E. Brightling, L. Brussino, E. Burte, M. Bustamante, G. W. Canonica, L. Cecchi, J. C. Celedon, C. Chaves Loureiro, E. Costa, A. A. Cruz, M. Erhola, B. Gemicioglu, W. J. Fokkens, J. Garcia‐Aymerich, S. Guerra, J. Heinrich, J. C. Ivancevich, T. Keil, L. Klimek, P. Kuna, M. Kupczyk, V. Kvedariene, D. E. Larenas‐Linnemann, N. Lemonnier, K. C. Lodrup Carlsen, R. Louis, M. Makela, M. Makris, M. Maurer, I. Momas, M. Morais‐Almeida, J. Mullol, R. N. Naclerio, K. Nadeau, R. Nadif, M. Niedoszytko, Y. Okamoto, M. Ollert, N. G. Papadopoulos, G. Passalacqua, V. Patella, R. Pawankar, N. Pham‐Thi, O. Pfaar, F. S. Regateiro, J. Ring, P. W. Rouadi, B. Samolinski, J. Sastre, M. Savouré, N. Scichilone, M. H. Shamji, A. Sheikh, V. Siroux, B. Sousa‐Pinto, M. Standl, J. Sunyer, L. Taborda‐Barata, S. Toppila‐Salmi, M. J. Torres, I. Tsiligianni, E. Valovirta, O. Vandenplas, M. T. Ventura, S. Weiss, A. Yorgancioglu, L. Zhang, A. H. Abdul Latiff, W. Aberer, I. Agache, M. Al‐Ahmad, I. Alobid, I. J. Ansotegui, S. H. Arshad, E. Asayag, C. Barbara, A. Baharudin, L. Battur, K. S. Bennoor, E. C. Berghea, K. C. Bergmann, D. Bernstein, M. Bewick, H. Blain, M. Bonini, F. Braido, R. Buhl, R. S. Bumbacea, A. Bush, M. Calderon, M. Calvo‐Gil, P. Camargos, L. Caraballo, V. Cardona, W. Carr, P. Carreiro‐Martins, T. Casale, A. M. Cepeda Sarabia, R. Chandrasekharan, D. Charpin, Y. Z. Chen, I. Cherrez‐Ojeda, T. Chivato, E. Chkhartishvili, G. Christoff, D. K. Chu, C. Cingi, J. Correia de Sousa, C. Corrigan, A. Custovic, G. D’Amato, S. Del Giacco, F. De Blay, P. Devillier, A. Didier, M. do Ceu Teixeira, D. Dokic, H. Douagui, M. Doulaptsi, S. Durham, M. Dykewicz, T. Eiwegger, Z. A. El‐Sayed, R. Emuzyte, A. Fiocchi, N. Fyhrquist, R. M. Gomez, M. Gotua, M. A. Guzman, J. Hagemann, S. Hamamah, S. Halken, D. M. G. Halpin, M. Hofmann, E. Hossny, M. Hrubiško, C. Irani, Z. Ispayeva, E. Jares, T. Jartti, E. Jassem, K. Julge, J. Just, M. Jutel, I. Kaidashev, O. Kalayci, A. F. Kalyoncu, P. Kardas, B. Kirenga, H. Kraxner, I. Kull, M. Kulus, S. La Grutta, S. Lau, L. Le Tuyet Thi, M. Levin, B. Lipworth, O. Lourenço, B. Mahboub, E. Martinez‐Infante, P. Matricardi, N. Miculinic, N. Migueres, F. Mihaltan, Y. Mohammad, M. Moniuszko, S. Montefort, H. Neffen, K. Nekam, E. Nunes, D. Nyembue Tshipukane, R. O’Hehir, I. Ogulur, K. Ohta, K. Okubo, S. Ouedraogo, H. Olze, I. Pali‐Schöll, O. Palomares, K. Palosuo, C. Panaitescu, P. Panzner, H. S. Park, C. Pitsios, D. Plavec, T. A. Popov, F. Puggioni, S. Quirce, M. Recto, M. S. Repka‐Ramirez, C. Robalo Cordeiro, N. Roche, M. Rodriguez‐Gonzalez, J. Romantowski, N. Rosario Filho, M. Rottem, H. Sagara, F. S. Serpa, Z. Sayah, S. Scheire, P. Schmid‐Grendelmeier, J. C. Sisul, D. Sole, M. Soto‐Martinez, M. Sova, A. Sperl, O. Spranger, R. Stelmach, C. Suppli Ulrik, M. Thomas, T. To, A. Todo‐Bom, P. V. Tomazic, M. Urrutia‐Pereira, M. Valentin‐Rostan, E. Van Ganse, M. van Hage, T. Vasankari, P. Vichyanond, G. Viegi, D. Wallace, D. Y. Wang, S. Williams, M. Worm, P. Yiallouros, O. Yusuf, F. Zaitoun, M. Zernotti, M. Zidarn, J. Zuberbier, J. A. Fonseca, T. Zuberbier, J. M. Anto +249 morewiley +1 more sourcePhenotype of BTK‐lacking myeloid cells during prolonged COVID‐19 and upon convalescent plasma
European Journal of Haematology, Volume 110, Issue 2, Page 209-212, February 2023., 2023 Abstract
XLA patient with 7‐month course of COVID‐19 with persistent plasma SARS‐CoV‐2 load revealed a sustained non‐inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS‐COV‐2 infection.André M. C. Gomes, Guilherme B. Farias, Amelia C. Trombetta, Ana Godinho‐Santos, Inês Parreira, Hélder Diogo Gonçalves, Mariana Lessa Simões, Patrício Aguiar, Maria Manuel Deveza, João Inácio, Ana E. Sousa, Susana Lopes da Silva +11 morewiley +1 more sourceCadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma
Molecular Oncology, Volume 16, Issue 14, Page 2611-2631, July 2022., 2022 Here, we identified Cadherin‐3 (CDH3) as a novel oncogene in glioblastoma (GBM). CDH3 affected distinct cancer hallmarks in vitro and was related to increased tumor growth and shorter survival in vivo. Clinically, CDH3 correlated with cancer‐related signatures and was overexpressed in a subset of patients with poor prognosis, thus suggesting that CDH3 ...Eduarda P. Martins, Céline S. Gonçalves, Marta Pojo, Rita Carvalho, Ana S. Ribeiro, Vera Miranda‐Gonçalves, Ricardo Taipa, Fernando Pardal, Afonso A. Pinto, Carlos Custódia, Cláudia C. Faria, Fátima Baltazar, Nuno Sousa, Joana Paredes, Bruno M. Costa +14 morewiley +1 more sourceMedicina Geral e Familiar em Portugal
Revista Brasileira de Medicina de Família e Comunidade, 2014 Nas últimas décadas, tem-se assistido em Portugal ao desenvolvimento da especialidade de Medicina Geral e Familiar (MGF), à semelhança daquilo que tem ocorrido em outros países europeus. No presente artigo, são descritas as diversas alterações, tanto no nível da carreira médica como no nível da formação, que vieram a culminar no atual modelo a partir ...Ana Costa, Raquel Pedro, Sara Magalhãesopenaire +3 more sourcesMedicina geral e familiar: ontem, hoje e amanhã
Revista Portuguesa de Clínica Geral, 2023 Quando queremos perspetivar o futuro podemos tentar adivinhar o amanhã, o que é complicado, ou podemos perceber o passado, entender o contexto, as circunstâncias e o impacto das decisões que nos trouxeram ao agora e extrapolar os resultados. Raramente acertaremos no que vai de facto acontecer, mas ficaremos com uma ideia muito concreta das opções que ...openaire +2 more sourcesTerapêutica subcutânea em cuidados paliativos
Revista Portuguesa de Medicina Geral e Familiar, 2005
Introdução: A pouca divulgação da via subcutânea (SC) em Portugal contraria a sua importância, necessidade e eficácia em situações específicas, nomeadamente em cuidados continuados e paliativos. Esta via é fundamental na administração de fármacos e de Cátia Marques, Gilda Nunes, Tiago Ribeira, Nuno Santos, Rodrigo Silva, Ricardo Teixeira +5 moredoaj +1 more source
