Results 81 to 90 of about 154,557 (271)

Razões para a falta a consultas médicas em unidades de medicina geral e familiar: um estudo transversal

Revista Portuguesa de Clínica Geral
Introdução: A informação sobre faltas às consultas de medicina geral e familiar (MGF) é escassa em Portugal. Objetivos: Estudar os motivos de falta a consultas de MGF em três Unidades de Saúde Familiar no centro de Portugal, em 2022, segundo as variáveis
Ana Carvalhais, João Pestana, Luiz Miguel Santiago   +2 more
semanticscholar   +1 more source

Successful Nonsurgical Management of Clostridium perfringens Sepsis With Massive Intravascular Hemolysis and Liver Abscess: A Case Report

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Background: Clostridium perfringens is an anaerobic, Gram‐positive, spore‐forming bacterium, commonly associated with gas gangrene and clostridial myonecrosis. Although bacteremia is rare, it carries a high mortality rate, particularly when complicated by massive intravascular hemolysis.
Diogo Costa Oliveira, Inês Mendonça, Carolina Vaz-Pinto, Cristina Marques, Alexandra Babo, Vasco Elói, Priya Gusain   +6 more
wiley   +1 more source

Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating drug

British Journal of Pharmacology, Volume 181, Issue 24, Page 5041-5061, December 2024.
Abstract Background and Purpose Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R‐selective agonist, MRS5474, has been reported to suppress seizures without considerable cardiac action ...
Anwesha Ghosh, Leonor Ribeiro‐Rodrigues, Gabriele Ruffolo, Veronica Alfano, Cátia Domingos, Nádia Rei, Dilip K. Tosh, Diogo M. Rombo, Tatiana P. Morais, Cláudia A. Valente, Sara Xapelli, Beatriz Bordadágua, Alexandre Rainha‐Campos, Carla Bentes, Eleonora Aronica, Maria José Diógenes, Sandra H. Vaz, Joaquim A. Ribeiro, Eleonora Palma, Kenneth A. Jacobson, Ana M. Sebastião   +20 more
wiley   +1 more source

Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar‐Kyoto rat model of depression

Journal of Neurochemistry, Volume 168, Issue 9, Page 2443-2460, September 2024.
We aimed at assessing anxiety‐ and depressive‐like behaviors in Wistar‐Kyoto (WKY) rats and determining whether these were associated to changes in levels of neuroinflammatory markers (Iba‐1, CD86, Ym1, GFAP, S100A10) and mediators (interleukins IL‐1β, IL‐6, TNF‐α) in the prefrontal cortex (PFC), hippocampus, and amygdala.
Miguel Farinha‐Ferreira, Daniela M. Magalhães, Mariana Neuparth‐Sottomayor, Hugo Rafael, Catarina Miranda‐Lourenço, Ana M. Sebastião   +5 more
wiley   +1 more source

Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy

Advanced Functional Materials, Volume 34, Issue 33, August 14, 2024.
A biodegradable multifunctional PLA‐based vaccine designed to co‐deliver in vivo breast cancer‐associated antigens (α‐Lac and KRAS), TLR ligands (CpG and Poly(I:C)) and siRNA TGF‐β1 to dendritic cells and tumor microenvironment (TME) induce a strong anti‐tumor immune‐mediated effect and sensitize the triple‐negative and luminal B‐like breast cancers to
Carina Peres, Ana I. Matos, Bárbara Carreira, Liane I. F. Moura, Ron Kleiner, Daniella Vaskovich‐Koubi, Keren Reshef, Shai Dulberg, Mafalda Verdial, João Conniot, Marta B. Afonso, Rita C. Acúrcio, Afonso P. Basto, Sofia Mensurado, Bruno Silva‐Santos, Susana Constantino Rosa Santos, Ana S. Viana, Liana C. Silva, Cecília M. P. Rodrigues, Véronique Préat, Luís Graça, Asaf Madi, Ronit Satchi‐Fainaro, Helena F. Florindo   +23 more
wiley   +1 more source

Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures

Small, Volume 20, Issue 29, July 18, 2024.
Here, tetrahedral DNA nanostructures (TDN) are evaluated as nano‐scaffolds for neuronal cell delivery of siRNA, exploring the functionalization with neuronal ligands (C4‐3 aptamer and Tet1 peptide). Aptamer‐functionalized TDN shows enhanced uptake in neuronal cells, and mediates efficient gene silencing when in the presence of an endosomal disruption ...
Ana S. G. Martins, Sara D. Reis, Erik Benson, Marco M. Domingues, João Cortinhas, Joana A. Vidal Silva, Sofia D. Santos, Nuno C. Santos, Ana P. Pêgo, Pedro M. D. Moreno   +9 more
wiley   +1 more source

Suplementação com ferro na criança saudável até aos dois anos de idade

Revista Portuguesa de Medicina Geral e Familiar, 2010
Objectivo: Determinar se a suplementação de rotina com ferro, na criança saudável até aos dois anos de idade, influencia o desenvolvimento psicomotor, antropometria e a morbimortalidade.
Luís Filipe Cavadas, Ana Nunes, Rosa Branca Santos, Joana Melo Adrião   +3 more
doaj   +1 more source

Testamento vital: uma ferramenta para fim de vida em todas as fases da vida

Revista Portuguesa de Medicina Geral e Familiar, 2023
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João R. Nunes Pires, Mariana Castro Guimarães, Ana Maria Alves, Ina Garuta, Raquel Baptista Leite   +4 more
doaj   +1 more source

Uma leitura sobre a medicina baseada na evidência a partir de Ludwik Fleck: entre incomensurabilidades e sincretismos [PDF]

, 2014
Tendo como base o contributo inovador de Fleck para o estudo do conhecimento médico, procura-se neste artigo explorar a ideia da incomensurabilidade entre estilos de pensamento.
Raposo, Hélder António
core   +1 more source

The effects of exogenous substances on the color of heated bones

American Journal of Biological Anthropology, Volume 184, Issue 2, June 2024.
Abstract Objectives Burned bone coloration has been used for decades to help in the bioanthropological analysis of burned human bones. However, there is a variety of factors that can interfere with the coloration manifested by bones exposed to heat, resulting in colors that differ from the usual black to white gradient.
Joana Rosa, Luís A. E. Batista de Carvalho, Francisco P. S. C. Gil, Maria Paula M. Marques, Maria Teresa Ferreira, David Gonçalves   +5 more
wiley   +1 more source