Results 201 to 210 of about 144,329 (265)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Noncoding RNAs and the phytochemical economy: Molecular regulators of secondary metabolism in medicinal plants. [PDF]

Biochem Biophys Rep
Ugwu OP, Ugwu MN, Onohuean H, Rather HA, Usman IM.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

In-silico identification of anti-cholera phytochemicals from Indian medicinal plants. [PDF]

PLoS One
Rahman K, Akter Y, Reza MS, Pappu MAA, Karim MR, Sultana M, Islam MT, Alam M, Mollah MNH, Monir MM.   +9 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Evaluation of Phytochemical Constituents, Antioxidant Potential, and Toxicological Profile of Selected Medicinal Plants from Romania's Spontaneous Flora. [PDF]

Molecules
Virchea LI, Georgescu C, Frum A, Máthé E, Mironescu M, Pecsenye B, Nagy R, Danci OV, Mureșan ML, Totan M, Gligor FG.   +10 more
europepmc   +1 more source

Medicinal Plants That Modulate Nitric Oxide Synthase Activity: Implications in Inflammation and Oxidative Stress. [PDF]

Drug Des Devel Ther
Prayoga DK, Aulifa DL, Budiman A, Jiranusornkul S, Levita J.   +4 more
europepmc   +1 more source

Metabolites Evaluation, Cytotoxicity, and Teratogenicity Analysis of Selected Medicinal Plants. [PDF]

Scientifica (Cairo)
Valentino MJG, Wahyuni TS.
europepmc   +1 more source

A global approach to safety assessment of medicinal plants. [PDF]

Bull World Health Organ
Patwardhan B, Chaturvedi S, Upton R, Hunter J, Wieland LS, El-Nabawy N, Chuthaputti A, Wei C, Donkor K, Sungchol K, Wolfram E, Gopalakrishna Pillai GK, Kuruvilla S.   +12 more
europepmc   +1 more source