Results 161 to 170 of about 76,525,237 (343)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Lower morbidity and disease risk among the Chinese medicine physicians in Taiwan

, 2010
[[abstract]]Healthy physicians are critical to the quality of care for patients. There is a common trend in Chinese societies seeking for medical treatments from Chinese medicine physicians. However, there are limited studies that investigated the health
Liu, SH;Li, TH;Lin, YL;Shiao, YJ;Wu, SC;Li, CY;Sung, FC;Yang, CY;Wu, TN
core   +1 more source

SGLT2i attenuates biventricular remodeling and preserves connexin 43 in experimental volume-overload heart failure

Scientific Reports
Heart failure (HF) caused by chronic volume overload is associated with progressive structural, electrical, and metabolic remodeling, leading to ventricular dysfunction and increased arrhythmogenic risk. Although sodium–glucose cotransporter-2 inhibitors
Matus Sykora, Katarina Ondrejak Andelova, Veronika Farkasova, Tamara Egan Benova, Natalia Andelova, Zuzana Honetschlagerova, Eva Goncalvesova, Narcis Tribulova, Barbora Szeiffova Bacova   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans

FASEB BioAdvances
The importance of macrophage polarization through atherogenesis is established. However, most studies rely on immunohistological approaches, which have several limitations, such as precluding comprehensive phenotypic analysis.
Barbora Muffova, Sona Kauerova, Hana Bartuskova, Karel Paukner, Libor Janousek, Helena Cermakova, Jiri Fronek, Marek Kollar, Marek Petras, Jan Pitha, Rudolf Poledne, Ivana Kralova Lesna   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

TRPV1 in skeletal muscles mediates the improvement of cardiac function induced by acupuncture at the PC6 acupoint in rats with acute myocardial infarction

Chinese Medicine
Background The acupoint is the initial response site to acupuncture stimulation, and changes in the acupoint affect the subsequent therapeutic effects of acupuncture. However, the mechanism of acupuncture from this initial site has not yet been clarified.
Xue Liu, Yongjian Wu, Yongxiao Zhai, Weifang Gao, Xiaoyu Meng, Wubo Pei, Yuxin Fang, Yi Guo, Yangyang Liu   +8 more
doaj   +1 more source