Results 31 to 40 of about 7,545,236 (293)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Precision medicine and traditional chinese medicine of dialogue [PDF]

, 2017
The precision medicine is more precise individualized medicine, based on the patient’s genes or physiological to formulate the specific treatment plan, for the realization of individualized treatment of various diseases to provide valuable information ...
Xin Lou, Ming Bai, Mingsan Miao, Bai Ming, Miao Mingsan, Lou Xin   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode [PDF]

, 2012
Background Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality
Yuan-Yuan Xie, Chen, Xi, Lv Shu-Feng, Liang, Q-L, Xu, Qing-Bo, Qing-Bo Xu, Liang Qiong-Lin, Cheng, Yi-Jun, Zhang, Q-L, Rong Gao, Xu, Q-B, Yi-Ming Wang, Zhang, Rong-Li, Xue Li, Gao, Rong, Lv, Shu-Feng, Zhang Rong-Li, Shu-Feng Lv, Xu Qing-Bo, Xi Chen, Xue-Mei Fan, Liang, Xiao-Ping, Liang Xiao-Ping, Jun Wu, Wu Jun, Xie Yuan-Yuan, Luo Guo-An, Zhang, Qing-Li, Zhang Hong-Yang, Xiao-Ping Liang, Gao, R, Luo, Guo-An, Xie, Yuan-Yuan, Zhang, Hong-Yang, Cheng, Y-J, Fan Xue-Mei, Zhang Qing-Li, Liang, Qiong-Lin, Xiao, Q-Z, Zhang, H-Y, Xiao, Qing-Zhong, Zhang, R-L, Yi-Jun Cheng, Chen, X, Wu, Jun, Xie, Y-Y, Luo, G-A, Qing-Li Zhang, Qiong-Lin Liang, Wang, Yi-Ming, Qing-Zhong Xiao, Lv, S-F, Gao Rong, Li Xue, Wang, Y-M, Wu, J, Fan, Xue-Mei, Cheng Yi-Jun, Hong-Yang Zhang, Wang Yi-Ming, Fan, X-M, Li, Xue, Liang, X-P, Guo-An Luo, Chen Xi, Xiao Qing-Zhong, Li, X, Rong-Li Zhang   +67 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Report from the Second International Conference of Traditional and Complementary Medicine on Health 2015 [PDF]

, 2016
The Second International Conference of Traditional and Complementary Medicine on Health was held from October 24th through 27th at the GIS National Taiwan University Convention Center in Taipei.
Isidoro, Ciro;Huang, Chia-Chi;Sheen, Lee-Yan, Ciro Isidoro, Sheen, Lee Yan, Huang, Chia Chi, ISIDORO, Ciro   +4 more
core   +1 more source