Results 171 to 180 of about 19,462,706 (409)

Educational Perspectives on Compassionate Concussion Care: A Scoping Review. [PDF]

Clin Teach
Kam ASH, Roy F, Wiljer D, Fernandez N, Richardson D.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017
V. Kapur, D. Auckley, S. Chowdhuri, David C Kuhlmann, R. Mehra, K. Ramar, C. Harrod   +6 more
semanticscholar   +1 more source

Effect of Isoniazid Resistance on Treatment Outcome Among People With Pulmonary Tuberculosis in Korea. [PDF]

J Korean Med Sci
Lee JM, Kim HW, Lee EG, Park Y, Jung SS, Kim JW, Oh JY, Lee H, Kim SH, Kim SH, Lyu J, Kwon SJ, Jeong YJ, Kim D, Koo HK, Chae G, Kyung SY, Lee SS, Park JS, Kim JS, Min J.   +20 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Advances in Mitochondrial Medicine

, 2012
Roberto Scatena, Patrizia Bottoni, Bruno Giardina   +2 more
openalex   +2 more sources

The current utilization and perceptions of prescription drug monitoring programs among emergency medicine providers in Florida [PDF]

, 2017
Henry W. Young, Joseph A. Tyndall, Linda B. Cottler   +2 more
openalex   +1 more source

Minerals in biology and medicine

, 2021
Oliver W. L. Carter, Yingjian Xu, Peter J. Sadler   +2 more
openalex   +2 more sources

Simulation-Based Bayesian Predictive Probability of Success for Interim Monitoring of Clinical Trials With Competing Event Data: Two Case Studies. [PDF]

Pharm Stat
Micoli C, Crippa A, Connor JT, I‐SPY COVID Consortium, Eklund M, Discacciati A.   +5 more
europepmc   +1 more source