Results 211 to 220 of about 9,123,523 (313)

One Medicine Doesn't Fit All [PDF]

open access: yesCancer Discovery, 2011
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

MEDICAL EVACUATION WITHIN SYSTEM OF LIQUIDATION OF MEDICAL AND SANITARY CONSEQUENCES OF CRISIS SITUATIONS

open access: yesМедицина катастроф, 2018
Baranova N.N.   +4 more
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Governance and Update Process for Lifestyle Medicine Core Competencies and Definitions. [PDF]

open access: yesAm J Lifestyle Med
Rea BL   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Rebuilding the foundation: recommendations from the Summit to Revitalize Primary Care (Rev PC). [PDF]

open access: yesBMC Proc
Summit to Revitalize Primary Care Writing Committee*   +17 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy