Results 241 to 250 of about 5,062,841 (308)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

All medicine is medicine; exploring inappropriate antibiotic use at the community level in rural Ghana

Journal of Infection and Public Health, 2020
S. Afari-Asiedu, M. Hulscher, E. Boamah-Kaali, M. Abdulai, K. Asante, H. Wertheim   +5 more
doaj  

Deep Learning-Based Landmark Detection Model for Multiple Foot Deformity Classification: A Dual-Center Study. [PDF]

Yonsei Med J
Lee SJ, Yoon H, Bae S, Paik I, Moon JH, Park S, Jang CW, Park JH, Choi E, Yang E, Shin JC.   +10 more
europepmc   +1 more source

Lung structure and function, post-treatment, in strictly defined subclinical pulmonary tuberculosis: a prospective cohort study in Canada. [PDF]

ERJ Open Res
Long R, Collins S, Stickland MK, Kirby M, Lau A, Barrie J, Winter C, Armstrong G, Wong E, Parhar A, Yehya J, Bourbeau J, Tan WC, Doroshenko A.   +13 more
europepmc   +1 more source

Effect of adjunctive intraoral balance appliance in the usual care of patients with chronic temporomandibular joint disorders using Korean medicine in South Korea: study protocol for a randomised controlled trial. [PDF]

BMJ Open
Shin WC, Kim SY, Cho W, Park J, Kim H, Chung WS, Song MY, Cho JH.   +7 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Academic Lifestyle Medicine and Physician Education. [PDF]

Am J Lifestyle Med
Rippe JM, Frates B.
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Rinaldo Bellomo - An Intensive Care Medicine Icon. [PDF]

Crit Care
McLean A, Dobb G.
europepmc   +1 more source