Results 341 to 350 of about 26,997,198 (419)

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

A distributional reinforcement learning model for optimal glucose control after cardiac surgery. [PDF]

NPJ Digit Med
Desman JM, Hong ZW, Sabounchi M, Sawant AS, Gill J, Costa AC, Kumar G, Sharma R, Gupta A, McCarthy P, Nandwani V, Powell D, Carideo A, Goodwin D, Ahmed S, Gidwani U, Levin MA, Varghese R, Filsoufi F, Freeman R, Shetreat-Klein A, Charney AW, Hofer I, Chan L, Reich D, Kovatch P, Kohli-Seth R, Kraft M, Agrawal P, Kellum JA, Nadkarni GN, Sakhuja A.   +31 more
europepmc   +1 more source

THE CONFERENCE OF WHO COLLABORATING CENTERS FOR EMERGENCY SITUATIONS, STOCKHOLM, SWEDEN, DECEMBER 5-7, 2017

Медицина катастроф, 2018
Kipor G.V., Baranova N.N., Goncharov S.F., Fisun A.Ya. , Chadov V.I.   +4 more
doaj  

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Cranial Arterial Perfusion of the Tympanic Bullae Region in Llamas (Lama glama): Anatomic Features and Anomalies. [PDF]

Anat Histol Embryol
Chamberlain TM, Anderson DE, Reed RB.
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Preferences on the Use of Prokinetic Agents in Adult Intensive Care Unit Patients-An International Survey. [PDF]

Acta Anaesthesiol Scand
Crone V, Møller MH, Alhazzani W, Grønningsæter L, Al-Fares A, Hästbacka J, Ostermann M, Pfortmueller CA, Ferrer R, Blaser AR, Sigurdsson MI, Wall O, Keus E, Szczeklik W, Young PJ, McGrath C, Cecconi M, Perner A, Krag M.   +18 more
europepmc   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Cardiac Arrest: An Adult eCPR Simulation Case. [PDF]

MedEdPORTAL
Gelmann D, Giordano J, Gaillard J, Bryant C.   +3 more
europepmc   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source