Results 161 to 170 of about 3,903,678 (356)

PERBEDAAN TINGKAT PENGETAHUAN KESEHATAN REPRODUKSI PADA REMAJA MAHASISWA FAKULTAS KEDOKTERAN DAN FAKULTAS ILMU SOSIAL DAN ILMU POLITIK UNIVERSITAS DIPONEGORO [PDF]

open access: yes, 2011
Background: The awareness of reproductive health are increasing, namely HIV/AIDS, unwanted pregnancy and unsafe abortion. This indicates that knowledge of reproductive health is important. This research aimed to identify reproductive health knowledge in
Bhramitasari, Weka   +2 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Recent Advancements in Reducing the Off-Target Effect of CRISPR-Cas9 Genome Editing

open access: yesBiologics: Targets & Therapy
Misganaw Asmamaw Mengstie,1 Muluken Teshome Azezew,2 Tadesse Asmamaw Dejenie,3 Assefa Agegnehu Teshome,4 Fitalew Tadele Admasu,1 Awgichew Behaile Teklemariam,1 Anemut Tilahun Mulu,1 Melaku Mekonnen Agidew,1 Dagnew Getnet Adugna,5 Habtamu Geremew,6 ...
Asmamaw Mengstie M   +10 more
doaj  

Buckeyes Without Borders [PDF]

open access: yes, 2013
IMPACT. 1: Beginning in 2009, BWB student member Cara Whalen forged partnerships between the Ubumwe Community Center (UCC), The Columbus Zoo and Aquarium's Partners In Conservation (PIC), and BWB to enable an interdisciplinary team of faculty and ...
Whalen, Cara N.
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A View of Healthscience --Based on the investigation of the current situation in Germany-- [PDF]

open access: yes, 1986
We examined the current situation of studies on health in Germany, especially medical anthropology by v. Weizsacker and v. Gebsattel, medical sociology, social medicine and general medicine in the faculties of medicine of German universities and the new ...
石井, 誠士
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Precision medicine, an approach for development of the future medicine technologies

open access: yesIranian South Medical Journal, 2016
Precision medicine is an approach in medicine that takes into account individual differences in people's genes, environments, and lifestyle. This field of medicine redefines our understanding of disease onset and progression, treatment response, and ...
Iraj Nabipour, Majid Assadi
doaj  

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