Results 61 to 70 of about 6,596,421 (354)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Longer Lives?: Understanding the Human Life Extension Possibilities [PDF]

open access: yes, 2017
Over the last few years, ethical and social issues related to life extension have gathered much attention among biologists, medical doctors and philosophers.
Garcia-Barranquero, Pablo
core  

Oral characteristics of Trisomy 8 and monosomy 18: a case report [PDF]

open access: yes, 2011
Several reports described various mosaic chromosomal syndromes characterized by alterations originated by either an excess or deficit in the number of chromosomes.
Campus, Guglielmo Giuseppe   +3 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

EVIDENCE-BASED MEDICINE – I. GENERAL PRINCIPLES

open access: yesZdravniški Vestnik, 2003
Background. Evidence-based medicine is a method that helps physicians find and critically evaluate evidences from the medical literature, and apply the evidences in clinical decision-making. In clinical practice the method supplements core medical skills,
Angela Čuk
doaj  

Rural Doctor Conversation [PDF]

open access: yes, 2010
South Asia in general, and India specifically, are regions with immense diversity in culture and language. Because of this conversations about medicine between doctors and patients takes different forms from one region to another. This is especially true
Joshi, Himanshu   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Diagnosis and Treatment Protocol for COVID-19 Patients (Tentative 9th Version)

open access: yes​​​​​​​​Infectious Diseases & Immunity, 2022
The General Office of National Health Commission & the General Office of National Administration of Traditional Chinese Medicine   +1 more
doaj   +1 more source

Why Compulsory Family Medicine for General Practice?

open access: yesSouth African Family Practice, 2003
No abstract available.
Jannie Hugo
doaj   +1 more source

short @nd sweet news : Nr. 9 [PDF]

open access: yes, 2007
* Change the Date: 1st Frankfurt General Practice Day * Summer Symposium of the Praxissiegel Foundation on July 6, 2007 * Revamp of the course "Introduction to Clinical Medicine" * Summer celebration for practice participants in the ...

core  

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