Results 61 to 70 of about 3,738,036 (312)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

IrGO: Iranian traditional medicine General Ontology and knowledge base. [PDF]

open access: yesJ Biomed Semantics, 2021
Naghizadeh A   +9 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Magnesium Preparations in Psychiatry, Addiction Medicine, Neurology and General Medicine (Part I. History)

open access: yesActa Biomedica Scientifica, 2019
The use of magnesium preparations in medicine has a long history. According to some sources, first attempts by humans to consume magnesium- and calcium-rich minerals orally, presumably for medicinal purposes, could have occurred even in prehistoric times.
A. R. Bekker   +3 more
doaj   +1 more source

Ophthalmology and general medicine [PDF]

open access: yesPostgraduate Medical Journal, 2000
This ophthalmological perspective of general medicine attempts to deal with the more common situations encountered clinically in general ophthalmic practice. Some priority has been given to the clinical usefulness of data. A comprehensive review would involve a wide range of rare conditions and has not been attempted.
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Real opinions on general medicine residency programs in Japan: Perspectives from medical students, residents, and young academic generalists

open access: yesJournal of General and Family Medicine, 2023
Kosuke Ishizuka   +5 more
doaj   +1 more source

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