Results 61 to 70 of about 14,864,087 (411)

The future of general medicine [PDF]

Clinical Medicine, 2014
It is a truth universally acknowledged that there is a problem with general medicine. Physicians have become increasingly specialised over the past 30 years or so, and specialist care has produced increasingly better outcomes for some patients. The patients left behind are looked after by general medicine, where demand is increasing, operational ...
openaire   +2 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Students’ perceptions of general medicine following community‐based medical education in rural Japan

Journal of general and family medicine, 2019
Japan's population is rapidly aging, and at the same time, the number of medical students interested in general or family medicine is declining. Community‐based medical education (CBME) programs may be used to promote interest and competencies in general
R. Ohta, Yoshinori Ryu, Takuji Katsube, Y. Moriwaki, J. Otani   +4 more
semanticscholar   +1 more source

Medicine is not science [PDF]

, 2014
: Abstract Most modern knowledge is not science. The physical sciences have successfully validated theories to infer they can be used universally to predict in previously unexperienced circumstances.
Miller, Clifford, Miller, Donald W.
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Systolic blood pressure levels and mortality in Australian medical inpatients

The Journal of Clinical Hypertension, 2023
The epidemiology of elevations in blood pressure is incompletely characterized, particularly in Australia. Given the lack of evidence regarding the frequency and the optimal management of in‐hospital hypertension, the authors performed a multicenter ...
Jin Nuo Joan Tsang, Stephen Bacchi, Joshua G. Kovoor, Aashray K. Gupta, Brandon Stretton, Samuel Gluck, Toby Gilbert, Yogesh Sharma, Richard Woodman, Arduino A. Mangoni   +9 more
doaj   +1 more source

Publication rates on the topic of racial and ethnic diversity in dermatology versus other specialties [PDF]

, 2020
Background: The population of the U.S. is becoming more diverse every year. The field of dermatology is not following the same trend. Objective: To assess the promotion of diversity in the field of dermatology by analyzing publications focused on ...
Bray, Jeremy K, Feldman, Steven R, Huang, William W, McMichael, Amy J   +3 more
core  

Ophthalmology and general medicine [PDF]

Postgraduate Medical Journal, 2000
This ophthalmological perspective of general medicine attempts to deal with the more common situations encountered clinically in general ophthalmic practice. Some priority has been given to the clinical usefulness of data. A comprehensive review would involve a wide range of rare conditions and has not been attempted.
openaire   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source