Results 51 to 60 of about 65,612 (263)

The impact of medicine shortages on customer work in community pharmacy

, 2023
Tämän kandidaatintutkielman tavoitteena on selvittää, kuinka lääkkeiden saatavuushäiriöt vaikuttavat asiakastyöhön apteekissa. Lääkkeiden saatavuushäiriöiden vaikutuksia tarkastellaan myös varastohallinnan näkökulmasta, sekä eri ammattiryhmien ...
Koponen, Nina
core  

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study [PDF]

Background: Drug shortages can negatively impact patient care. We aimed to estimate the incidence and prevalence of use of medicines with shortages announced by the European Medicines Agency between January, 2013, and September, 2023, and to characterise
Lopez Gomez, Carlos, Claire, Ravinder, Mayer, Miguel Angel, Moscetti, Luca, Maljković, Filip, Manlik, Katrin, Garcia-Torrens, Salvador, Rijnbeek, Prof Peter R, Pérez, Álvaro Martínez, Rekkas, Alexandros, Fey, Eric, Prieto Alhambra, Daniel, Bruninx, Erwin, Sánchez-Sáez, Francisco, Şen, Selçuk, Gomez, Carlos Lopez, Pericàs Pulido, Pau, Pineda‐Moncusí, Marta, Rappoport, Nadav, Rodeiro, Jordi, Price, Prof David Brendan, Martínez Pérez, Álvaro, Rodeiro-Boliart, Jordi, Prieto-Alhambra, Daniel, Mayer, Miguel-Angel, Tadrous, Mina, Burkard, Theresa, Kiss, Loretta, Eleangovan, Neva, Tadrous, Assoc prof Mina, Cooper, Steven R., Sanchez‐Saez, Francisco, Zsuzsa Kiss, Loretta, Price, David Brendan, Natsiavas, Pantelis, Leis, Angela, Merkelbach, Manon, Reisberg, Sulev, Pineda-Moncusí, Marta, Pulido, Pau Pericàs, Price, David, Rijnbeek, Peter R., Franz, Michael, Pineda Moncusi, Marta, Cooper, Steven   +44 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of medicines shortages on pharmaceutical practice

Romanian Journal of Pharmaceutical Practice, 2022
Access to medicines is a fundamental human right and is a vital element of health care. Over the last 10 years, there has been a tendency for the global discontinuation of drug supply to become a major problem, with an increasing exacerbation of this phenomenon in the European Union, with a potential negative impact on patient health care due to ...
Alin-Viorel Focsa, Magdalena Birsan, Maria Dragan, Ruxandra Teodora Stan, Cornelia Mircea, Catalina Daniela Stan   +5 more
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Development of the European Veterinary Medicines Gaps and Needs Compass for Sheep and Goats Based on Online Survey and Expert Knowledge Elicitation

Veterinary Sciences
Limited availability of veterinary medicinal products (VMPs) for small ruminants is a long-standing challenge. This mixed-methods study provides the first systematic definition and assessment of (i) shortages, (ii) lack of availability and (iii) unmet ...
Nikola Čudina, Marina Marić, Lauren Chambers, Margot Vidalinc, Anne Katrine Aagaard, Javier Balado, Petra Bratić, Martin Ganter, Allan Hägg Grønborg, Hasan Hüseyin Şenyüz, Antonio Spezzigu, Aikaterini Pazarakioti, Clare Phythian, Rianne van Helden, Panagiotis D. Katsoulos, Arturo Anadón, Laure Baduel, Flore Demay, Rens van Dobbenburgh, Shereene Williams, Janos Kovacs, Jobke van Hout, Frane Božić, Nancy De Briyne, Wiebke Jansen   +24 more
doaj   +1 more source

The effects of pricing policy on the prices and supply of low-cost medicines in Shandong, China: evidence from an interrupted time series analysis

BMC Public Health, 2020
Background In China, some medicines had a supply problem. In 2015, to address this problem, the Chinese government issued a policy to raise the price cap for some shorted low-cost medicines (LCMs).
Xuejing Rong, Jia Yin, Shuoyun Duan, Qiang Sun, Zaheer-Ud-Din Babar   +4 more
doaj   +1 more source

Additional file 1 of Impact of medicine shortages on patients - a framework and application in the Netherlands

, 2022
Additional file 1. Supplement – Impact of medicine shortages on patients: application on learning cases.
Hubert G. M. Leufkens (12514391), Kim Notenboom (2570947), Aukje K. Mantel-Teeuwisse (9084875), Peter A. G. M. De Smet (14140405), Doerine J. Postma (14140402)   +4 more
core   +1 more source