Results 301 to 310 of about 3,617,077 (391)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Feasibility of drone-based sputum sample and medicine transport for tuberculosis diagnosis in Yadadri-Bhuvanagiri District of Telangana, India: A qualitative study. [PDF]

Digit Health
Kamble BD, Nigam K, Aggarwal S, Panda M, Potukuchi G, Ganji V, Kundapur R, Agarwal N, Bhatia V.   +8 more
europepmc   +1 more source

Establishing a non-profit community-based research driven lifestyle medicine organization [PDF]

Du Plessis, Maira M-J-S, Plessis Du, Maira M.   +1 more
openalex  

Hannah Halliwell, Art, Medicine, and Femininity: Visualising the Morphine Addict in Paris, 1870–1914, Montreal, Canada: McGill-Queen's University Press, 2024, 240 pp., ISBN: 9780228019909.

Cynthia Jones Sadler
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Substandard and falsified medicines in Africa: healthcare systems challenges, supply chain issues, regulatory challenges and strategies to increase access to quality medicines. [PDF]

Front Pharmacol
Chabalenge B, Sahota T, Ermolina I, Tanna S.   +3 more
europepmc   +1 more source

Important families and the 'professional' elite within brazilian medicine

, 1997
Coradini, Odaci Luiz
openalex   +1 more source

Stopping Before Harm: Adaptive Sandhi Thresholds for Dose and Intervention Control in Medicine

Uthraa Murali
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source