Results 21 to 30 of about 5,375 (154)

Anatomical information science [PDF]

, 2005
The Foundational Model of Anatomy (FMA) is a map of the human body. Like maps of other sorts – including the map-like representations we find in familiar anatomical atlases – it is a representation of a certain portion of spatial reality as it exists at ...
Kumar, Anand, Mejino, Jose L V, Rosse, Cornelius, Schultz, Stefan, Smith, Barry   +4 more
core   +2 more sources

Preclinical development and characterization of a human plasma‐derived high‐purity factor X concentrate for therapeutic use

Haemophilia, Volume 29, Issue 6, Page 1394-1409, November 2023., 2023
Abstract Introduction Hereditary factor X deficiency is a rare bleeding disorder, with limited treatment options. This paper describes the approach to pre‐clinical development and characterization of a high‐purity plasma‐derived factor X concentrate, to achieve orphan drug marketing authorization for the treatment of hereditary factor X deficiency ...
Joanne Lloyd, Peter Feldman
wiley   +1 more source

Long‐term safety of tenapanor in patients with irritable bowel syndrome with constipation in the T3MPO‐3 study

Neurogastroenterology &Motility, Volume 35, Issue 11, November 2023., 2023
A total of 90 patients received ≥52 weeks of treatment with tenapanor across the parent (T3MPO‐1 and T3MPO‐2) and T3MPO‐3 studies, with a mean tenapanor exposure of 375.2 days. Just over half of patients experienced a TEAE. Diarrhea was the most common TEAE, with the majority being mild or moderate in intensity.
Anthony J. Lembo, Keith A. Friedenberg, Ronald P. Fogel, Susan Edelstein, Suling Zhao, Yang Yang, David P. Rosenbaum, William D. Chey   +7 more
wiley   +1 more source

Evaluation of patient‐reported outcome measures for on‐demand treatment of hereditary angioedema attacks and design of KONFIDENT, a phase 3 trial of sebetralstat

Clinical and Translational Allergy, Volume 13, Issue 9, September 2023., 2023
Abstract Background Hereditary angioedema (HAE) with C1‐inhibitor deficiency (HAE‐C1‐INH) is characterized by recurrent, debilitating episodes of swelling. Sebetralstat, an investigational oral plasma kallikrein inhibitor, demonstrated promising efficacy for on‐demand treatment of HAE‐C1‐INH in a phase 2 trial.
Danny M. Cohn, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Henriette Farkas, William R. Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, Marc A. Riedl   +12 more
wiley   +1 more source

B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity. [PDF]

Ann Clin Transl Neurol
Abstract This post hoc analysis of the randomized, placebo‐controlled N‐MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD) evaluated relationships between circulating B‐cell subsets and aquaporin‐4 immunoglobulin G (AQP4‐lgG) titers and attacks.
Bennett JL, Pittock SJ, Paul F, Kim HJ, Irani SR, O'Connor KC, Patterson KR, Smith MA, Gunsior M, Mittereder N, Rees WA, Cimbora D, Cree BAC.   +12 more
europepmc   +2 more sources

Conserving tropical biodiversity via market forces and spatial targeting [PDF]

, 2015
The recent report from the Secretariat of the Convention on Biological Diversity [(2010) Global Biodiversity Outlook 3] acknowledges that ongoing biodiversity loss necessitates swift, radical action.
Badura, Tomas, Bateman, Ian, Binner, Amy, Carbone, Chris, Coombes, Emma, Fisher, Brendan, Fitzherbert, Emily, Naidoo, Robin, Watkinson, Andrew   +8 more
core   +2 more sources

Defining Renal Recovery in Patients With Hepatorenal Syndrome-Acute Kidney Injury: Experience From North American Studies. [PDF]

JGH Open
ABSTRACT Introduction The degree of improvement in serum creatinine (SCr) has previously been suggested as a sensitive indicator of treatment response in patients with hepatorenal syndrome‐acute kidney injury (HRS‐AKI), while HRS reversal remains the primary endpoint in clinical trials.
Mujtaba MA, Elsiesy H, Faiz S, Hussain SA, Gamilla-Crudo AKN, Karim A, Khan MI, Khattak MW, Zafar Z, Kueht M, Jamil K.   +10 more
europepmc   +2 more sources

Electronic health record standards [PDF]

, 2006
Objectives: This paper seeks to provide an overview of the initiatives that are proceeding internationally to develop standards for the exchange of electronic health record (EHR) information between EHR systems.Methods: The paper reviews the clinical and
Kalra, D
core   +1 more source

The 13 th world congress on medical and health informatics, Cape Town, South Africa: Partnerships for effective e-Health solutions

Journal of Pathology Informatics, 2011
The 13 th World Congress on Medical and Health Informatics (Medinfo) was held in 2010 between 12 and 15 September in Cape Town, South Africa. This triennial international gathering is the official conference of the International Medical Informatics ...
Andrew Georgiou
doaj   +1 more source

Aus der AGMB

GMS Medizin – Bibliothek – Information, 2014
[english] We look back to the Annual Meeting of the German MLA (AGMB) 2014 in Mannheim and ahead to the Annual Meeting of the German MLA (AGMB) 2015 in Basel. A new head of the working team “Libraries in Pharmaceutical Industry” is introduced.
Hentschel, Eike
doaj   +1 more source