Results 141 to 150 of about 5,015 (181)

Diversity of Plant Communities Surrounding the Hot Springs on the Eastern Flank of the Sierra Madre Oriental, Northeastern Mexico. [PDF]

Biology (Basel)
Pantoja-Irys JR, de la Rosa-Manzano E, Martínez-Ávalos JG, Guerra-Pérez A, Mora-Olivo A, Arellano-Méndez LU, Serna-Márquez R, Salmerón-Carreño ED, Mujica-Sánchez H.   +8 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Analysis of the influence of apparent temperature on hypertension outpatient visits in Haikou city using a distributed lag nonlinear model. [PDF]

Medicine (Baltimore)
Zhang M, Yang J, Zhang Y, Lin S, Zhang J.   +4 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Mining Thermophile Photosynthesis Genes: A Synthetic Operon Expressing <i>Chloroflexota</i> Species Reaction Center Genes in <i>Rhodobacter sphaeroides</i>. [PDF]

Biomolecules
Rehman Y, Kim Y, Tong M, Blaby IK, Blaby-Haas CE, Beatty JT.   +5 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Effects and differences of various concentration techniques on the evolution of therapeutic components in Lushan geothermal water. [PDF]

Sci Rep
Zhang B, Fang Z, Xuan K, Ma W, Gao B, Liu Y, Huang D, Xie S, Ding Y.   +8 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Isolation of genome-predicted Caldatribacterium (Atribacterota) reveals pervasive microbial cultivation problem due to folate precipitation. [PDF]

Nat Commun
Hedlund BP, Alvarado T, Sushenko NS, Murphy TR, Torres A, Blocker AM, Lai D, Mayali X, Seymour CO, Muok A, Xiao R, Levon E, Phoenix JT, Mazdra K, Sons T, Doss RK, Vamvakas A, Camacho A, Ledesma J, Jiries J, Manriquez A, Martinez AR, Owerkowicz Z, Lacy J, Weber PK, Briegel A, Moser DP, Pett-Ridge J, Dodsworth JA, Hamilton-Brehm SD.   +29 more
europepmc   +1 more source

Green and Scalable Synthesis of Efficient and Stable CsPbBr3 Perovskite Quantum Dots Enables Low‐Threshold Amplified Spontaneous Emission

Advanced Science, EarlyView.
Green and scalable synthesis of CsPbBr3 perovskite quantum dots using bio‐sourced lecithin and hexane enables single‐batch production over 10 grams. Suppressed Auger recombination and electron‐phonon coupling yields 95% PLQY, enhanced stability, and low ASE thresholds of 230.4 (ns) and 50.1 (fs) µJ cm−2 in neat films. ABSTRACT Halide perovskite quantum
Yongfeng Liu, Mengting Zhang, Qingyu Xie, Kehao Hu, Bowen Zhang, Zhe Zhang, Jie Yang, Zhiping Hu, Juan Du, Jia Wang, Min Zhou   +10 more
wiley   +1 more source