Results 131 to 140 of about 33,885 (292)

Perspective for small and medium-sized cities development (German experience)

, 2013
Рефлексия по поводу возможности развития событийного туризма в малых и средних городах.Reflection on the possibilities of event tourism development in small and medium-sized ...
Эйхельберг, Е. А., Eichelberg, E.   +1 more
core  

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

The medium-sized cities as equilibrium nodules of a network of cities

, 2012
Os estudos da rede urbana brasileira têm avançado para diversos campos e, sem dúvida, um dos que se destaca, atualmente, é aquele que trata do papel desempenhado pelas denominadas cidades médias. Mesmo porque, a análise desta categoria de centro urbano tornou-se obrigatória, pois são determinantes no atual processo de desconcentração da economia ...
Ramos, Edivaldo Fernandes, da Silva Matos, Ralfo Edmundo, Garcia, Ricardo Alexandrino   +2 more
openaire   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

The medium-sized cities as nodules of equilibrium of network cities

, 2000
Studies of Brazilian urban network have advanced to a variety of fields and, without doubt, one of which stands today, is one that deals with the role played by so-called medium-sized cities. Even because, the analysis of this category of urban center became compulsory, as are decisive in the current process of devolution of the Brazilian economy ...
Fernandes Ramos, Edivaldo, da Silva Matos, Ralfo Edmundo, Garcia, Ricardo Alexandrino   +2 more
openaire   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

Advanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Bikeways and Sustainable University Mobility in Medium-Sized Cities: A Geospatial Analysis of Potential Use in Loja, Ecuador

Future Transportation
University mobility in medium-sized cities faces increasing challenges arising from traffic congestion, urban sprawl, and the limited availability of sustainable transport options.
Fabián Díaz-Muñoz, Xavier Merino-Vivanco   +1 more
doaj   +1 more source

On the Image Structure for the "Medium Size City"

Journal of the City Planning Institute of Japan, 1987
Shimizu, Koshiro, Kimura, Kazuhiro, Kimura, Nobuyuki, Furuyama, Mitsunori   +3 more
openaire   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source