Results 101 to 110 of about 182,045 (280)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

An improved TDM-based controller for a multilevel three-phase active frontend with variable DC ratios: The extended Negev rectifier

Alexandria Engineering Journal
This paper presents an improved Time-Division-Multiplexing (TDM) based controller for a recently introduced multilevel three-phase (3ɸ) active frontend called the Negev rectifier.
Eli Barbie, Dmitry Baimel
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Impact of Photovoltaics Power Plant Penetration on a Closed-Loop Distribution Network's Power Quality Indices

Journal of Sustainable Development of Energy, Water and Environment Systems
The integration of high levels of photovoltaic power plants into existing networks in recent years has brought significant opportunities in terms of greenhouse gas reduction, help to increase the security of supply, and creating new job options as well ...
Klajdi Kamberi, Donard Shaliu, Marialis Çelo, Andi Hida, Viktor Rrotani   +4 more
doaj   +1 more source

Analysis of Visible-Light Image and Flashover Voltage on the Cap-and-Pin Insulator With Fan-Shaped Pollution Distribution

IEEE Access
Previous models have examined the relationship between insulator pollution level and flashover voltage, as well as between pollution levels and image-based features.
Mochammad Wahyudi, Tumiran Tumiran, Noor Akhmad Setiawan   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Performance assessment of modern distribution networks conjoined with electric vehicles in normal and faulty conditions

Scientific African
With global efforts underway to reduce greenhouse gas emissions and protect the world's finite oil sources, the advent of electric vehicles (EVs) has emerged as a viable solution to address these imperatives.
Abdullah M. Shaheen, Aya R. Ellien, Ali M. El-Rifaie, Adel A. El-Ela, Eman S. Ali   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ultrasound-Assisted Melt Extrusion of Polymers with the Main Harmonics of 10–60 kHz

Fluids
Using a digital oscilloscope, the main harmonics resulting from the application of different frequencies and power levels of ultrasonic waves during the polymer extrusion process were identified.
Diana Agüero-Valdez, Alain González-Sánchez, María Teresa Rodríguez-Hernández, Heidi Andrea Fonseca-Florido, Juan Guillermo Martínez-Colunga, Janett Anaid Valdez-Garza, Gilberto Francisco Hurtado-López, Víctor Javier Cruz-Delgado, Carlos Alberto Ávila-Orta   +8 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source