Results 201 to 210 of about 4,509,271 (313)

International Pain and Spine Intervention Society Emergency Protocols: Intradural or Intrathecal Local Anesthetic Injection. [PDF]

Interv Pain Med
Nagpal AS, Klessinger S, Waring PH, Schneider BJ.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inequality in human development amplifies climate-related disaster risk. [PDF]

Nat Commun
Teber K, Sippel S, Krause M, Zscheischler J, Mahecha MD.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Microbiologically influenced corrosion (MIC) potential of bentonite microorganisms: implications for a deep geological repository for nuclear waste. [PDF]

World J Microbiol Biotechnol
Černá K, Mukhtar SS, Bureš R, Alfaro-Espinoza G, Koerdt A, Říha J, Hlavackova V, Stoulil J.   +7 more
europepmc   +1 more source

Lysine acetylome profiling reveals a dual regulatory role in carbon flux redirection and RNA degradation inhibition in <i>Mycobacterium smegmatis</i>. [PDF]

Front Microbiol
Sun M, Zhao Q, Zhou C, Liu C, Yang B, Bu J, Li R, Bian J, Niu X, Hu J, Liu B, Ge S.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Spent Medium Inhibits rVSV Infection. [PDF]

Viruses
Habisch R, Wieland JG, Kessler S, Neubauer P, Soza-Ried J, Puschmann E.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Small molecules promote the in vitro expansion and passaging of adult mouse pancreatic islets. [PDF]

Biochem Biophys Rep
Zhang L, Liu K, Zhang X, Cui Y, Hu H, Hu X.   +5 more
europepmc   +1 more source