Results 51 to 60 of about 3,451 (284)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Lightweight TiVNb medium-entropy alloy with weak strength dependence on temperature. [PDF]

Heliyon
Herein, a TiVNb medium-entropy alloy was prepared via vacuum arc melting. The alloy maintained a body-centred cubic (BCC)-dominant phase following an annealing treatment at 1300 °C for 12 h. Although its structure was coarsened due to grain growth during
Jiang Y, Yang Q, Liu YR, Chang H.
europepmc   +2 more sources

Martensitic transformation and mechanical behavior of a medium-entropy alloy

, 2020
Diffusionless martensitic transformation (MT) exerts one of the most significant influences on the mechanical properties of alloys. However, the application of martensitic transformation to improve mechanical performance was seldom involved in the ...
Lin, K. F., Wang, C., Yang, T., Liu, W. H., Liu, C. T., Lin, H. C., Hsueh, C. H., Kai, J. J., Zhao, Y. L., Zhang, T. L.   +9 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Lattice structures and mechanical properties of FeCrNi medium-entropy alloy prepared by selective laser melting

Cailiao gongcheng
Metal lattice structural materials are widely used in aerospace, automotive industry, and other fields due to their advantages of lightweight, high specific strength, energy absorption, and porosity.
SUN Chi, WANG Jian, HE He, QIN Dongyang, CAO Yuankui, FU Ao, LIU Bin   +6 more
doaj   +1 more source

Effective and back stresses evolution upon cycling a high-entropy alloy

Materials Research Letters, 2022
We report on the effective and back stresses evolution of a CoCrFeMnNi high-entropy alloy (HEA) by partitioning its cyclic hysteresis loops. It was found that the cyclic stress response of the HEA predominantly originates from the back stress evolution ...
Kaiju Lu, Ankur Chauhan, Fabian Knöpfle, Jarir Aktaa   +3 more
doaj   +1 more source

Preparation of nanoporous CoCr alloy by dealloying CrCoNi medium entropy alloys

Journal of Materials Research and Technology, 2020
High/Medium entropy alloys (H/MEAs) represent a new strategy for the design of materials with properties superior to those of conventional alloys. Here, we show a new field of application where the uniform mixtures of multiple principal elements in H/MEAs is utilized to create new type nanoporous alloys by dealloying. By using equiatomic CrCoNi MEAs as
Longfei Zeng, Chaoping You, Xufeng Cai, Chunming Wang, Xuehui Zhang, Tongxiang Liang   +5 more
openaire   +2 more sources

Corrosion behaviour of Al-Fe-Ti-V medium entropy alloy

, 2017
: Alloys containing up to four multi-principal elements in equiatomic ratios are referred to as medium entropy alloys (MEA). These alloys have attracted the interest of many researchers due to the superior mechanical properties it offers over the ...
Obadele, B.A., Olubambi, P.A., L H Chown, P A Olubambi, Chown, L.H., M O Bodunrin, B A Obadele, Bodunrin, M.O.   +7 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source