Results 11 to 20 of about 20,957 (246)

Double Salts and Racemate in Mefloquine-Ibuprofen and Mefloquine-Ketoprofen Systems. A Structural and Thermochemical Analysis. [PDF]

Chirality
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Martins JB, Segatto JV, Tenorio JC, Carvalho PS.   +3 more
europepmc   +2 more sources

Electrical Synapses Contribute to Sleep-Dependent Declarative Memory Retention. [PDF]

Eur J Neurosci
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Feld GB, Niethard N, Liu J, Gebhardt S, Kleist L, Brugger K, Fritsche A, Born J, Ngo HV, Hallschmid M.   +9 more
europepmc   +2 more sources

Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

European Journal of Medicinal Chemistry, 2010
Raoní S B Gonçalves, Marcus V N De Souza, James L Wardell   +2 more
exaly   +3 more sources

Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity against Mycobacterium tuberculosis

Molecules, 2022
The development of novel pharmaceutical tools to efficiently tackle tuberculosis is the order of the day due to the rapid development of resistant strains of Mycobacterium tuberculosis. Herein, we report novel potential formulations of a repurposed drug,
Dário Silva, Márcio V. C. Lopes, Željko Petrovski, Miguel M. Santos, Jussevania P. Santos, Sueli F. Yamada-Ogatta, Marcelle L. F. Bispo, Marcus V. N. de Souza, Ana Rita C. Duarte, Maria C. S. Lourenço, Raoni Schroeder B. Gonçalves, Luis C. Branco   +11 more
doaj   +1 more source

Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures. [PDF]

PLoS ONE, 2013
Mefloquine is widely used for the treatment of malaria. However, this drug is known to induce neurological side effects including depression, anxiety, balance disorder, and sensorineural hearing loss.
Dalian Ding, Weidong Qi, Dongzhen Yu, Haiyan Jiang, Chul Han, Mi-Jung Kim, Kana Katsuno, Yun Hua Hsieh, Takuya Miyakawa, Richard Salvi, Masaru Tanokura, Shinichi Someya   +11 more
doaj   +1 more source

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo, Flohe, Moreno, Viode, Henderson, Walsh, Krauth-Seigel, Muller, Nogoceke, Tetaud, Wilkinson, Wilkinson, Tetaud, Wilkinson, Boveris, Fairlamb, Mehlotra, Carnieri, Kendall, Kelly, Gibson, Martinez-Calvillo, Kelly, Kelly, Kelly, Cannata, Rutter, Easterby, Gommel, Steinert, Sommer, Opperdoes, Opperdoes, Michels, Parsons, Blattner, Bjornstedt, Sztajer, Horiguchi, Holgren, Fabianek, Shih, Shih, van den Bosch, Subramani, Keller, Singh, Singh, Boveris, Duffieux, Goodman, Knoops, Yamashita, Verdoucq, Seo, Lopez, Krieger   +56 more
core   +4 more sources

Anti-malaria drug mefloquine induces motor learning deficits in humans

Frontiers in Neuroscience, 2010
Mefloquine (a marketed anti-malaria drug) prophylaxis has a high risk of causing adverse events. Interestingly, animal studies have shown that mefloquine imposes a major deficit in motor learning skills by affecting the connexin 36 gap junctions of the ...
Thomas A Van Essen, Ruben S Van Der Giessen, S K E Koekkoek, Frans van der Werf, Chris I De Zeeuw, Perry J J Van Genderen, David Overbosch, Marcel T G De Jeu   +7 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Mefloquine

Reactions Weekly, 2006
europepmc   +5 more sources

Population pharmacokinetics of mefloquine given as a 3-day artesunate–mefloquine in patients with acute uncomplicated Plasmodium falciparum malaria in a multidrug-resistant area along the Thai–Myanmar border

Malaria Journal, 2018
Background Low mefloquine exposure has been shown to contribute to treatment failure in patients with uncomplicated falciparum malaria following a 3-day artesunate–mefloquine combination.
Richard M. Hoglund, Ronnatrai Ruengweerayut, Kesara Na-Bangchang   +2 more
doaj   +1 more source