Results 41 to 50 of about 20,957 (246)

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial.

PLoS Neglected Tropical Diseases, 2014
BackgroundTreatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Jennifer Keiser, Kigbafori D Silué, Lukas K Adiossan, Nicaise A N'Guessan, N'Chou Monsan, Jürg Utzinger, Eliézer K N'Goran   +6 more
doaj   +1 more source

The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Malaria Journal, 2003
Background There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of the drug on endoplasmic ...
Vahey Maryanne, Hudson Thomas H, Dow Geoffrey S, Koenig Michael L   +3 more
doaj   +1 more source

Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats.

PLoS ONE, 2020
The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections.
Aaron M Izes, Benjamin Kimble, Jacqueline M Norris, Merran Govendir   +3 more
doaj   +1 more source

Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis

Malaria Journal, 2009
Background Mefloquine has historically been considered safe and well-tolerated for long-term malaria chemoprophylaxis, but prescribing it requires careful attention in order to rule out contraindications to its use. Contraindications include a history of
Nevin Remington L
doaj   +1 more source

Psychosis with paranoid delusions after a therapeutic dose of mefloquine: a case report

Malaria Journal, 2006
Background Convenient once-a-week dosing has made mefloquine a popular choice as malaria prophylaxis for travel to countries with chloroquine-resistant malaria. However, the increased use of mefloquine over the past decade has resulted in reports of rare,
Browning Joseph, Tran Tuan M, Dell Mary L   +2 more
doaj   +1 more source

Continuous release of mefloquine featured in electrospun fiber membranes alleviates epidural fibrosis and aids in sensory neurological function after lumbar laminectomy

Materials Today Bio, 2022
Recurrent low back pain after spinal surgeries, such as lumbar laminectomy, is a major complication of excessive epidural fibrosis. Although multiple preclinical and clinical methods have been aimed at ameliorating epidural fibrosis, their safety and ...
Zhihao Yue, Bo Hu, Zhe Chen, Genjiang Zheng, Yunhao Wang, Chen Yang, Peng Cao, Xiaodong Wu, Lei Liang, Fazhi Zang, Jianxi Wang, Jing Li, Tao Zhang, Jinglei Wu, Huajiang Chen   +14 more
doaj   +1 more source

Plasmodium knowlesi Genome Sequences from Clinical Isolates Reveal Extensive Genomic Dimorphism. [PDF]

, 2015
Plasmodium knowlesi is a newly described zoonosis that causes malaria in the human population that can be severe and fatal. The study of P. knowlesi parasites from human clinical isolates is relatively new and, in order to obtain maximum information from
A Conesa, A Ecker, A Pain, A Sinha, AR Quinlan, B Langmead, B Singh, B Singh, C Aurrecoechea, C Daneshvar, C Hertz-Fowler, CJ Sutherland, EV Meyer, FA Fatih, H Li, I Kozarewa, J Cox-Singh, J Cox-Singh, Janet Cox-Singh, JB Koenderink, JC Barrett, JC Barrett, JC de Roode, JC Rayner, Julian C. Rayner, K Rutherford, KS Lee, L Mamanova, LH Miller, LH Miller, M Ashburner, M Rougemont, M Yuda, MA Ahmed, Md Atique Ahmed, Miguel M. Pinheiro, Osamu Kaneko, P Jones, P Librado, PC Divis, PM Jones, R Leinonen, R Tanizaki, R Tripathi, S Iwanaga, S Purcell, Sanjeev Krishna, Scott B. Millar, SE Lindner, SO Oyola, SW Roy, T Carver, T William, TC Yeo, Theo Sanderson, Thomas D. Otto, U Bronner, Woon Chan Lu, YL Lau   +58 more
core   +4 more sources

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source

Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Background: Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses.
Sean T. Windle, Kristin D. Lane, Nahla B. Gadalla, Anna Liu, Jianbing Mu, Ramoncito L. Caleon, Rifat S. Rahman, Juliana M. Sá, Thomas E. Wellems   +8 more
doaj   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source