Results 71 to 80 of about 20,957 (246)

Crystal structure and Hirshfeld surface analysis of 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 2-hydroxy-2-phenylacetate hemihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2016
The asymmetric unit of the title salt, C17H17F6N2O+·C8H7O3−·0.5H2O, comprises a pair of pseudo-enantiomeric (i.e. related by a non-crystallographic centre of symmetry) piperidin-1-ium cations, two carboxylate anions and a water molecule of ...
James L. Wardell, Mukesh M. Jotani, Edward R. T. Tiekink   +2 more
doaj   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag, Ademowo, George, Arze, Cesar, Asaq Molecular Marker Study Group, Baliraine, Frederick N, Berens-Riha, Nicole, Björkman, Anders, Borrmann, Steffen, Checchi, Francesco, Dahal, Prabin, Davis, Timothy ME, Desai, Meghna, Dhorda, Mehul, Djimdé, Abdoulaye A, Dorsey, Grant, El-Sayed, Badria B, Eshetu, Teferi, Eyase, Frederick, Falade, Catherine, Faucher, Jean-François, Fröberg, Gabrielle, Gadalla, Nahla B, Grivoyannis, Anastasia, Guérin, Philippe, Hamour, Sally, Houzé, Sandrine, Johnson, Jacob, Kamugisha, Erasmus, Kariuki, Simon, Kiechel, Jean-René, Kironde, Fred, Kofoed, Poul-Erik, LeBras, Jacques, Malmberg, Maja, Moriera, Clarissa, Mwai, Leah, Mårtensson, Andreas, Ménard, Didier, Ngasala, Billy, Nosten, Francois, Nsanzabana, Christian, Nsobya, Samuel L, Nzila, Alexis, Oguike, Mary, Ogutu, Bernhards, Otienoburu, Sabina Dahlström, Ouédraogo, Jean-Bosco, Piola, Patrice, Plowe, Christopher V, Price, Ric N, Rombo, Lars, Rosenthal, Philip J, Schramm, Birgit, Sibley, Carol Hopkins, Somé, A Fabrice, Stepniewska, Kasia, Sutherland, Colin J, Thwing, Julie, Ursing, Johan, Venkatesan, Meera, Wong, Rina PM, Zeynudin, Ahmed, Zongo, Issaka   +62 more
core   +4 more sources

Progression of Malaria in the Human Body, Its Effects on the Liver and Its Various Aspects

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Malaria, an infectious disease caused by Plasmodium parasites, is a significant global health issue, particularly in tropical and subtropical regions. Understanding the development of malaria in the human body and its effects on vital organs like the liver is crucial for effective control and prevention.
Avishek Mandal, Sanmoy Karmakar, Mithun Bhowmick, Sweet Naskar, Ankita Sadhukhan, Arnab Sarkar, Prativa Bhowmick, Jiong Yu   +7 more
wiley   +1 more source

Prevalence of Plasmodium Species Using Rapid Diagnostic Tests in Cameroon: First‐Year Data From Routine Malaria Surveillance

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a major public health concern in Cameroon. Although Plasmodium falciparum is the predominant parasite, the prevalence of other Plasmodium species remains poorly documented due to the absence of a formal surveillance system.
Raymond Ngomdjum Tabue, Flora Neh, Elvira Evina, Dominique Amougou Bomba, Junior Voundi Voundi, Jean Fosso, Albert Meka Zeh, Yoel A. Klug   +7 more
wiley   +1 more source

A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.

PLoS ONE, 2007
BackgroundMulti-drug resistant falciparum malaria is an important health problem in the Peruvian Amazon region. We carried out a randomised open label clinical trial comparing mefloquine-artesunate, the current first line treatment in this region, with ...
Tanilu Grande, Andrea Bernasconi, Annette Erhart, Dioni Gamboa, Martin Casapia, Christopher Delgado, Kathy Torres, Caterina Fanello, Alejandro Llanos-Cuentas, Umberto D'Alessandro   +9 more
doaj   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam, Ariey, Frederic, Chotivanich, Kesinee, Das, Debashish, Day, Nicholas PJ, Dondorp, Arjen M, Hanpithakpong, Warunee, Herdman, Trent, Imwong, Mallika, Lee, Sue J, Lim, Pharath, Lindegardh, Niklas, Lwin, Khin Maung, Nosten, François, Phyo, Aung Phae, Ringwald, Pascal, Silamut, Kamolrat, Singhasivanon, Pratap, Socheat, Duong, Tarning, Joel, White, Nicholas J, Yeung, Shunmay, Yi, Poravuth   +22 more
core   +1 more source

Unveiling Antimalarial Drug Resistance: The Role of CRISPR‐Cas Technologies in Malaria Research

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Malaria, caused by Plasmodium parasites, remains a global health burden, with drug resistance threatening control efforts. CRISPR‐Cas technologies, particularly CRISPR‐Cas9, have transformed malaria research by enabling precise genetic manipulations to study antimalarial resistance mechanisms, develop novel therapeutics and enhance ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Moses Okpeku, Jess Vergis   +3 more
wiley   +1 more source

The still under-investigated role of cognitive deficits in PML diagnosis [PDF]

, 2017
Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-treated MS patients, the importance of cognitive deficits in PML diagnosis is still under ...
Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Bresciamorra, Vincenzo, Capobianco, Marco, Capra, Ruggero, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Clerico, Marinella, Cordioli, Cinzia, Cosottini, Mirco, D'Aleo, Giangaetano, de Riz, Marilena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Gerevini, Simonetta, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Mattioli, Flavia, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Prosperini, Luca, Rezzonico, Monica, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpazza, Cristina, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Tabiadon, Giulia, Tortorella, Carla, Trojano, Maria, Valentino, Paola   +49 more
core   +2 more sources

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase [PDF]

, 2017
The antimalarial drug mefloquine has promising antischistosomal properties killing haematophagous adult schistosomes as well as schistosomula. The mode of action and involved drug targets of mefloquine in Schistosoma mansoni schistosomula are unknown. In
KEISER, JENNIFER, MANNECK, THERESIA, MÜLLER, JOACHIM   +2 more
core