Results 1 to 10 of about 69 (68)
Megaloblastic Anemia of Pregnancy: Characteristics of Pure Megaloblastic Anemia and Megaloblastic Anemia Associated with Iron Deficiency [PDF]
Blood, 1960 Abstract Morphology of the peripheral blood and bone marrow, iron, folic acid and vitamin B12 metabolism and estimation of erythrokinetics have been made in 17 patients with megaloblastic anemia of pregnancy. The peripheral blood showed the classic picture of megaloblastic anemia of pregnancy previously reported.
Henry Wallis +5 more
openaire +3 more sources
Understanding erythroid physiology and pathology in humanized mice: A closer look
British Journal of Haematology, Volume 206, Issue 5, Page 1272-1284, May 2025.Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu +7 more
wiley +1 more source
Annals of Neurology, Volume 97, Issue 6, Page 1190-1204, June 2025.At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard +22 more
wiley +1 more source
Acta Psychiatrica Scandinavica, Volume 151, Issue 6, Page 719-730, June 2025.ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per +5 more
wiley +1 more source
Congenital Familial Megaloblastic Anemia [PDF]
Blood, 1971 Abstract Two sisters with a previously unreported megaloblastic anemia unassociated with a deficiency of either folic acid or vitamin B12 are described. Deficiencies of these vitamins were ruled out by standard studies. All other previously reported forms of megaloblastic anemia not secondary to a vitamin deficiency, such as orotic ...
Carol B. Hyman +5 more
openaire +3 more sources
Journal of Diabetes Investigation, Volume 16, Issue 6, Page 1020-1027, June 2025.The concomitant use of metformin and PPI was significantly associated with an increased risk of vitamin B12 deficiency in patients with type 2 diabetes. ABSTRACT Introduction Vitamin B12 deficiency is one of the adverse drug reactions of metformin and proton pump inhibitors (PPIs).
Choungwon Jung, Soyoung Park, Hyunah Kim
wiley +1 more source
Impact of Metformin Therapy on Vitamin B12 Levels in Patients With Type 2 Diabetes Mellitus
Endocrinology, Diabetes &Metabolism, Volume 8, Issue 3, May 2025.The association between metformin treatment in type 2 DM and vitamin B12 deficiency. ABSTRACT Introduction Diabetes mellitus (DM) is a serious health condition affecting people worldwide with a high prevalence rate. DM is classified according to its aetiology into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM); several risk factors
Sahar H. Mahmoud +3 more
wiley +1 more source
JIMD Reports, Volume 66, Issue 3, May 2025.ABSTRACT In this report, we present the case of a 16‐month‐old patient who was diagnosed with cobalamin G deficiency at 4 months of age via whole exome sequencing by detecting compound heterozygous variants of uncertain significance (VUS) in the MTR gene: (1) c.1283T>A, p.Met428Lys; (2) c.2411T>C, p.Ile804Thr. Before the diagnosis, the initial clinical
Chi‐Tang Wu +3 more
wiley +1 more source
United European Gastroenterology Journal, Volume 13, Issue 4, Page 599-613, May 2025.ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti +29 more
wiley +1 more source
Megaloblastic Anemia from Methophenobarbital [PDF]
Blood, 1958 Abstract A 39-year-old spinster presented with a severe megaloblastic anemia after treatment of her epilepsy for eight years with the barbiturate, methophenobarbital, taken regularly and alone in therapeutic dose. This drug appears to have caused the anemia, which may have been conditioned by a folic-acid-poor diet. Hematologic remission
E. Hurworth +2 more
openaire +3 more sources