Results 31 to 40 of about 7,138 (202)

L‐quebrachitol Modulates the Anti‐convulsant Effects of Carbamazepine Possibly Through Voltage‐gated Sodium Channel Blocking Mechanism in Chicks: In Vivo and In Silico Studies

Brain and Behavior, Volume 15, Issue 7, July 2025.
L‐quebrachitol exhibited significant anticonvulsant effects in PTZ‐induced seizures in chicks, likely through voltage‐gated sodium channel inhibition. In vivo and in silico analyses suggest LQB may synergize with carbamazepine, offering a potential new therapeutic approach for epilepsy management. ABSTRACT Introduction L‐Quebrachitol (LQB), a naturally
Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Congenital Familial Megaloblastic Anemia [PDF]

Blood, 1971
Abstract Two sisters with a previously unreported megaloblastic anemia unassociated with a deficiency of either folic acid or vitamin B12 are described. Deficiencies of these vitamins were ruled out by standard studies. All other previously reported forms of megaloblastic anemia not secondary to a vitamin deficiency, such as orotic ...
Carol B. Hyman, Beatrice C. Lampkin, Beatrice C. Lampkin, Denman Hammond, Allan Pyesmany, Allan Pyesmany   +5 more
openaire   +3 more sources

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults

Annals of Neurology, Volume 97, Issue 6, Page 1190-1204, June 2025.
At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard, Ahmed Abdelhak, Rowan Saloner, Simone Sacco, Shivany C. Montes, Frederike C. Oertel, Christian Cordano, Nour Jabassini, Kirtana Ananth, Apraham Gomez, Azeen Keihani, Makenna Chapman, Sree Javvadi, Shikha Saha, Adam Staffaroni, Christopher Songster, Martin Warren, John W. Boscardin, Joel Kramer, Bruce Miller, Joshua W. Miller, Ralph Green, Ari J. Green   +22 more
wiley   +1 more source

Evaluation of Clinical Profile and Hematological Parameters of Cases of Megaloblastic Anemia

National Journal of Community Medicine, 2017
Background: Megaloblastic anemia is not uncommon in India. In India, the most common cause of megaloblastic anemia is nutritional where as it is the pernicious anemia in Northern Europe. Aims and objectives: To study age and gender-wise distribution,
Hemang N Suthar, Tejas N Shah
doaj  

Vitamin B12 Deficiency Resembling Acute Leukemia: A Case Report

Journal of Nepal Medical Association, 2021
Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy ...
Nisha Sharma, Saru kunwar, Anil Kumar Shrestha   +2 more
doaj   +1 more source

Qualitative and Quantitative Blood Cell Disorders Among High‐Level Antiretroviral Therapy‐Experienced Children in Northwest Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background and Aims The human immunodeficiency virus (HIV) and its treatment are commonly associated with blood cell morphological and numerical abnormalities. As a result, routine examination of blood disorders among HIV patients is necessary to minimize related complications and improve patients' prognosis.
Dereje Mengesha Berta, Biruk Bayleyegn, Solomon Getawa, Zewudu Mulatie, Tiruneh Adane, Elias Chane, Bisrat Birke Teketelew, Melak Aynalem   +7 more
wiley   +1 more source

Novel Homozygous Variant in the SLC19A2 Gene Causing Thiamine Responsive Megaloblastic Anemia Syndrome: A Disease to Be Considered in Diabetes Clinics

Endocrinology Research and Practice
Thiamine-responsive megaloblastic anemia (TRMA) syndrome is a rare syndrome with an autosomal recessive manner that develops due to a mutation in the SLC19A2gene.
Burak Canvar Helvacı, Hanife Saat , Sema Hepsen, Özant Helvacı, Erman Çakal   +4 more
doaj   +1 more source

Megaloblastic Anemia from Methophenobarbital [PDF]

Blood, 1958
Abstract A 39-year-old spinster presented with a severe megaloblastic anemia after treatment of her epilepsy for eight years with the barbiturate, methophenobarbital, taken regularly and alone in therapeutic dose. This drug appears to have caused the anemia, which may have been conditioned by a folic-acid-poor diet. Hematologic remission
E. Hurworth, A. L. Macbean, R. J. Calvert   +2 more
openaire   +3 more sources

European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN

United European Gastroenterology Journal, Volume 13, Issue 5, Page 773-797, June 2025.
ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti, Heinz Florian Hammer, Ilja Tacheci, Rosa Burgos, Stephane Schneider, Anastasiou Foteini, Aleksejs Derovs, Jutta Keller, Ilse Broekaert, Marianna Arvanitakis, Dan Lucian Dumitrascu, Oscar Segarra‐Cantón, Željko Krznarić, Juris Pokrotnieks, Gonçalo Nunes, Johann Hammer, Loris Pironi, Marc Sonyi, Cristina Maria Sabo, Juan Mendive, Adrien Nicolau, Jernej Dolinsek, Denisa Kyselova, Lucrezia Laterza, Antonio Gasbarrini, Teodora Surdea‐Blaga, Jorge Fonseca, Christos Lionis, Gino Roberto Corazza, Antonio Di Sabatino   +29 more
wiley   +1 more source

The Impact of Metformin on Weight and Waist Circumference in Patients Treated With Clozapine: A One‐Year Retrospective Cohort Study

Acta Psychiatrica Scandinavica, Volume 151, Issue 6, Page 719-730, June 2025.
ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per, Susan Loeser, Suzanne Edwards, Wen Siew Lee, Lisa R. Wilton, Scott Richard Clark   +5 more
wiley   +1 more source