Results 61 to 70 of about 159,853 (262)

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides by a Covalent Catch‐and‐Release Approach

Angewandte Chemie, EarlyView.
A glycan having a hydrazide tag enables chemoenzymatic synthesis of HS oligosaccharides. The hydrazide can, under mild acidic conditions, react with an aldehyde‐containing resin to give an immobilized hydrazone that is stable under neutral conditions, allowing washing. The product can be released by transiminolysis using aqueous hydroxylamine to give a
Francesco Palmieri, Chin Huang, Digantkumar Chapla, Kelley W. Moremen, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Developing a high-performance AI model for spontaneous intracerebral hemorrhage mortality prediction using machine learning in ICU settings

BMC Medical Informatics and Decision Making
Background Spontaneous intracerebral hemorrhage (SICH) is a devastating condition that significantly contributes to high mortality rates. This study aims to construct a mortality prediction model for patients with SICH using four various artificial ...
Xiao-Han Vivian Yap, Kuan-Chi Tu, Nai-Ching Chen, Che-Chuan Wang, Chia-Jung Chen, Chung-Feng Liu, Tee-Tau Eric Nya, Ching-Lung Kuo   +7 more
doaj   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T‐1

Angewandte Chemie, EarlyView.
A stereoselective functionalization method of cyclic imines under mild organocatalytic conditions was developed. Bifunctional cinchona alkaloid catalysts combined with carefully optimized reaction conditions to suppress background reactivity enabled highly enantio‐ and diastereoselective addition reactions of malonates to cyclic imines.
Frederic Kölblin, Helma Wennemers
wiley   +2 more sources

Effects of Different Varieties on Physicochemical Properties, Browning Characteristics, and Quality Attributes of Mume fructus (Wumei)

Foods
The dried Mume fructus (MF) is a special food and herbal medicine with a long history of processing and application. The browning index (BI) of Prunus mume (PM) is pivotal in determining the medicinal value and edible quality of MF.
Lei Gao, Hui Zhang, Hui Wang, Tao Wang, Aichao Li, Hongmei Xiao, Yihao Liu, Zhian Zheng   +7 more
doaj   +1 more source

Positive Selection and Functional Divergence at Meiosis Genes That Mediate Crossing Over Across the Drosophila Phylogeny

G3: Genes, Genomes, Genetics, 2019
Meiotic crossing over ensures proper segregation of homologous chromosomes and generates genotypic diversity. Despite these functions, little is known about the genetic factors and population genetic forces involved in the evolution of recombination rate
Cara L. Brand, Lori Wright, Daven C. Presgraves   +2 more
doaj   +1 more source

Separating Presentation And Content In Mei. [PDF]

, 2012
[TODO] Add abstract here.
Pugin Laurent, Kepper Johannes, Perry Roland, Hartwig Maja, Hankinson Andrew   +4 more
openaire   +2 more sources

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source