Results 61 to 70 of about 416,488 (313)

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

open access: yesAdvanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu   +10 more
wiley   +1 more source

Nota introduttiva / Introduction [PDF]

open access: yes, 2016
Il volume raccoglie i contributi scritti dai relatori che hanno partecipato al ciclo di conferenze Spazi pubblici e luoghi condivisi. Progetti architettonici per le città europee, ideato da Guya Bertelli e coordinato dal sottoscritto. Il symposium è
MEI, PASQUALE
core  

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

open access: yesAdvanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu   +11 more
wiley   +1 more source

Chitosan‐Carbon Dot Composite Materials Form a Leaf Surface Barrier to Mitigate the Enrichment and Invasion of Nanoplastics: From Leaf Interface to Systemic Response

open access: yesAdvanced Science, EarlyView.
Foliar spraying of CS‐CDs can form a film on the leaves of Brassica rapa, effectively reducing the enrichment and absorption of PS in the leaves, while increasing the biomass and nutrient content of the plants. In addition, CS‐CDs can also enrich the interfoliar microbial community and activate the plant's own defense metabolic pathways.
Beibei Zhao   +6 more
wiley   +1 more source

Yin zhu mei Boyan wen. [PDF]

open access: yes, 1937
梅曾亮著.書名據版權頁Mei Zengliang zhu.Detailed notes in vernacular field ...

core  

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

open access: yesAdvanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai   +8 more
wiley   +1 more source

Dopo l'"ultimo" testimone artista [PDF]

open access: yes, 2020
Il dossier "Per Carlo Quartucci" è composto da interventi d’artista (il ricordo dedica di Giuliano Scabia e il messaggio alato di Carla Tatò), ricostruzioni storico-critiche (di Donatella Orecchia e Lorenzo Mango), stralci di poetica (la trascrizione ...
MEI S
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New Roads for Patron-Driven E-books:Collection Development and Technical Services Implications of a Patron-Driven Acquisitions Pilot at Rutgers [PDF]

open access: yes, 2011
Collection development librarians have long struggled to meet user demands for new titles. Too often, required resources are not purchased, while some purchased resources do not circulate.
Lo, Mei Ling, De Fino, Melissa
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

open access: yesAdvanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang   +17 more
wiley   +1 more source

Empreendedorismo e Desenvolvimento Local. Uma Análise do Programa Microempreendedor Individual em Minas Gerais

open access: yesDesenvolvimento em Questão, 2016
Entrepreneurship has been a much discussed topic both in national and international literature.However, few studies have been concerned with public policies related to small businesses and theirrelations with local development.
Donizeti Leandro de Souza   +3 more
doaj  

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