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Meibomian gland dysfunction [PDF]

Indian Journal of Ophthalmology
Meibomian gland dysfunction (MGD) is a common chronic condition, affecting millions worldwide, and is one of the most frequent pathologies observed on a daily basis by eye specialists throughout the world. In the last decade, MGD has become recognised as
Murugesan Vanathi
doaj   +5 more sources

Targeted therapies for meibomian gland dysfunction – The role of antibiotics in meibomian gland dysfunction management [PDF]

Taiwan Journal of Ophthalmology
Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye, significantly impairing the quality of life. Bacterial proliferation and inflammation play central roles in the pathogenesis of MGD, creating a vicious cycle of gland ...
Reiko Arita
doaj   +5 more sources

Latest developments on meibomian gland dysfunction: Diagnosis, treatment and management [PDF]

African Vision and Eye Health, 2022
Background: Meibomian gland dysfunction (MGD) is one of the leading causes of evaporative dry eye disease and one of the most common ophthalmic conditions found in clinical practice.
Solani D. Mathebula
doaj   +3 more sources

Candidate Molecular Compounds as Potential Indicators for Meibomian Gland Dysfunction

Frontiers in Medicine, 2022
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease throughout the world. Studies have shown that several molecules in meibum, including but not limited to interleukins, amino acids, cadherins, eicosanoids, carbohydrates, and ...
Kofi Asiedu
doaj   +2 more sources

Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction [PDF]

Scientific Reports, 2023
Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social burdens. Because meibomian gland dysfunction results in impaired function of the tear film lipid layer, studying the ...
Andrea M. Storås, Fredrik Fineide, Morten Magnø, Bernd Thiede, Xiangjun Chen, Inga Strümke, Pål Halvorsen, Hilde Galtung, Janicke L. Jensen, Tor P. Utheim, Michael A. Riegler   +10 more
doaj   +2 more sources

Meibomian gland dysfunction in Sjögren's disease. [PDF]

Front Med (Lausanne)
For many years, lacrimal gland dysfunction was considered the primary cause of dry eye disease in Sjögren's Disease (SjD). However, recent studies reveal that meibomian gland dysfunction (MGD) is also a significant contributor in dry eye associated with SjD.
Anuwa-Amarh EN, Ziemanski JF.
europepmc   +4 more sources

Establishment of Mouse Meibomian Gland Organoids for In Vitro Modeling of Meibomian Gland Dysfunction. [PDF]

Invest Ophthalmol Vis Sci
To establish a three-dimensional model of the mouse meibomian gland (MG) and to recapitulate meibomian gland dysfunction (MGD) for pathological investigations in MGD.Primary mouse MG epithelial cells (MGECs) were embedded in Matrigel and expanded in serum-free medium, followed by the addition of extra growth factors to induce branching.
Qu J, Yang L, Wang X, Zhao L, Li Z, Zhang X, Lin Y, Guo Q, Zhao H, Zhong Y, Xie L, Zhou Q.   +11 more
europepmc   +3 more sources

Ferroptosis in Meibomian Gland Progenitor Cells Contributes to Pathogenesis of Meibomian Gland Dysfunction. [PDF]

Invest Ophthalmol Vis Sci
Meibomian gland (MG) atrophy in Meibomian gland dysfunction (MGD) is critically linked to progenitor cell (PC) abnormalities. However, the mechanisms underlying PC abnormalities during MGD pathogenesis remain unclear. This study investigates the role of ferroptosis in MG PC abnormalities during MGD pathogenesis.Three mouse MGD models were established ...
Guo Y, Luo S, Li W, Wang X, Sun W, Zha W, Zhang R, Liu D, Wei M, Zhang H, Liu Q, Liu Z.   +11 more
europepmc   +3 more sources

Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications [PDF]

International Journal of Ophthalmology, 2021
Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation.
Li-Xiang Wang, Ying-Ping Deng
doaj   +1 more source

Epithelial stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease

JCI Insight, 2021
Dry eye disease affects over 16 million adults in the US, and the majority of cases are due to Meibomian gland dysfunction. Unfortunately, the identity of the stem cells involved in Meibomian gland development and homeostasis is not well elucidated. Here,
Edem Tchegnon, Chung-Ping Liao, Elnaz Ghotbi, Tracey Shipman, Yong Wang, Renee M. McKay, Lu Q. Le   +6 more
doaj   +1 more source