Results 81 to 90 of about 130,251 (209)

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas [PDF]

, 2018
FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to pathologies associated with paradoxical ERK1/2 activation in wild-type BRAF cells.
Aplin, Andrew E., Berger, Adam C., Bollag, Gideon, Davies, Michael A., Goldberg, Allison F., Hartsough, Edward J., Knudsen, Karen E., Kugel, Curtis H., Purwin, Timothy J., Schiewer, Matthew J., Vido, Michael J.   +10 more
core   +1 more source

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]

, 2017
Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa, Barnette, Basalyga, Bonow, Brown-Augsburger, Brunskill, Brunskill, Chung, Fondard, Franco, Gallegos, Gapski, Ghosh, Gu, Helske, Hinton, Hinton, Holm, Ihn, Iverson, Jensen, Keane, Krenz, Liang, Lindeman, Marshall, Mercer, Mohler, Mozaffarian, Munjal, Nishimura, Nkomo, Perrotta, Poggio, Potter, Rajamannan, Rossebo, Sauls, Schmieder, Schoen, Starcher, Vesely, Wirrig, Wylie-Sears, Xiong, Xiong   +45 more
core   +2 more sources

Local, Sustained, and Targeted Co-Delivery of MEK Inhibitor and Doxorubicin Inhibits Tumor Progression in E-Cadherin-Positive Breast Cancer

Pharmaceutics
Effectively utilizing MEK inhibitors in the clinic remains challenging due to off-target toxicity and lack of predictive biomarkers. Recent findings propose E-cadherin, a breast cancer diagnostic indicator, as a predictor of MEK inhibitor success.
Paul M. Kuhn, Gabriella C. Russo, Ashleigh J. Crawford, Aditya Venkatraman, Nanlan Yang, Bartholomew A. Starich, Zachary Schneiderman, Pei-Hsun Wu, Thi Vo, Denis Wirtz, Efrosini Kokkoli   +10 more
doaj   +1 more source

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Frontiers in Pharmacology, 2015
Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination.
S. Lindsey eDavis, S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, Todd M. Pitts, John J. Tentler, John J. Tentler, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, John J. Arcaroli, Wells A. Messersmith, Wells A. Messersmith, Aik Choon eTan, Aik Choon eTan, S. Gail eEckhardt, S. Gail eEckhardt   +23 more
doaj   +1 more source

Synergistic induction of autophagy in gastric cancer by targeting CDK4/6 and MEK through AMPK/mTOR pathway

Heliyon
KRAS is a commonly mutated oncogene in human gastric cancer and is often associated with drug resistance and poor prognosis. Co-clinical trial of combined MEK-CDK4/6 inhibition in KRAS mutated cancers demonstrated therapeutic efficacy in patient-derived ...
Hong Zhou, Guiling Li, Liuyue Kan, Mingyu Yang, Yu Liu, Xiaye Miu, Lei Shi, Zhanjun Yang, Xucai Zheng, Hui Chen, Chuanli Ren   +10 more
doaj   +1 more source

MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy.

PLoS ONE, 2016
Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not completely understood. Herein, we sought to elucidate the molecular background of GC resistance in B-ALL
Anna Polak, Przemysław Kiliszek, Tomasz Sewastianik, Maciej Szydłowski, Ewa Jabłońska, Emilia Białopiotrowicz, Patryk Górniak, Sergiusz Markowicz, Eliza Nowak, Monika A Grygorowicz, Monika Prochorec-Sobieszek, Dominika Nowis, Jakub Gołąb, Sebastian Giebel, Ewa Lech-Marańda, Krzysztof Warzocha, Przemysław Juszczyński   +16 more
doaj   +1 more source

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). [PDF]

, 2017
A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model.
Bouvet, Michael, Clary, Bryan M, Delong, Jonathan C, Hoffman, Robert M, Hwang, Ho Kyoung, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Lwin, Thinzar M, Murakami, Takashi, Unno, Michiaki   +10 more
core  

Registered report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Vidhu Sharma, Lisa Young, Miguel Cavadas, Kate Owen, Reproducibility Project: Cancer Biology   +4 more
doaj   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer

JCI Insight
Loss of ferroptosis contributes to the development of human cancer, and restoration of ferroptosis has been demonstrated as a potential therapeutic strategy in cancer treatment.
Jiaxin Yin, Jianfeng Chen, Jing Han Hong, Yulin Huang, Rong Xiao, Shini Liu, Peng Deng, Yichen Sun, Kelila Xin Ye Chai, Xian Zeng, Jason Yongsheng Chan, Peiyong Guan, Yali Wang, Peili Wang, Chongjie Tong, Qiang Yu, Xiaojun Xia, Choon Kiat Ong, Bin Tean Teh, Ying Xiong, Jing Tan   +20 more
doaj   +1 more source