Results 221 to 230 of about 284,171 (356)
Aging Cell, EarlyView.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
THE TIME OF X-RAY INDUCTION OF CROSSOVERS AND OF TRANSLOCATIONS IN DROSOPHILA MELANOGASTER MALES [PDF]
, 1958 Lee E. Schacht
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, 2014 Homotropus melanogaster (Holmgren 1872, Bassus) Diagnosis. Fore wing length 3.8–4.7 mm. Antenna in females with 17 to 19 flagellomeres, apical flagellomeres with multiporous plate sensilla also present ventrally; in males with 19 to 20 flagellomeres and with narrow, long tyloids on flagellomeres 7 to 14–16.
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Aging Cell, EarlyView.Dietary sterols are essential nutrients for maintaining intestinal barrier integrity. Sterol competition caused by female reproduction exacerbates intestinal barrier damage during aging, thereby shortening female lifespan. ABSTRACT The trade‐off between reproduction and lifespan has been documented across a wide array of organisms, ranging from ...
Guixiang Yu +3 more
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Untersuchungen über den gelben Augenfarbstoff der Mutante „sepia“ von Drosophila melanogaster [PDF]
, 1956 Rolf Danneel, Berthilde Eschrich
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Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging
Aging Cell, EarlyView.Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom +26 more
wiley +1 more source
Journal of Evolutionary Biology, Volume 36, Issue 1, Page 264-279, January 2023., 2023 We show that within‐population level body size plasticity in response to combinations of temperature and nutrition is distinct from mean population level plastic response. This means that different genotypes within a population vary in the extent of nutritional plasticity of wing size depending on their rearing temperature (25ºC vs 28ºC).
Avishikta Chakraborty +5 more
wiley +1 more source
Mutant Isoalleles at the Vermilion Locus in Drosophila Melanogaster
, 1952 M. M. Green
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Variation and Dominance at the Scute Locus in Drosophila Melanogaster [PDF]
, 1959 J M RENDEL
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A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
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