Results 241 to 250 of about 552,068 (289)

Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCα-Induced β-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression. [PDF]

Int J Mol Sci
Ei ZZ, Racha S, Zou H, Chanvorachote P.
europepmc   +1 more source

Animal model of human disease. Malignant melanoma.

, 1976
Harold J. Sobel, E Marquet, Klaus D. Kallman, Glenna J. Corley   +3 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Imperfection in Semiconductors Leading to High Performance Devices

Advanced Science, EarlyView.
Crystalline perfection is typically pursued in semiconductors to enhance device performance. However, through modeling and experimental work, we show that defects can be strategically employed in a specific detection regime to increase sensitivity to extreme values. GaN diodes are demonstrated to effectively detect high‐energy proton beams at fluxes as
Jean‐Yves Duboz, Matilde Siviero, Lucas Lesourd, Eric Frayssinet, Sebastien Chenot, Petter Hofverberg, Sullivan Marafico, Marie Vidal, Maxime Hugues   +8 more
wiley   +1 more source

Integrating Single-Cell and Spatial Transcriptomics Reveals NK Cell Subpopulations Associated With Immunotherapy for Melanoma. [PDF]

Smart Med
Hu Z, Chen Y, Yang H, Pan Q, Li H, Li S, Wang J, Huang Y, Huang G, Qu S.   +9 more
europepmc   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Harnessing the synergy of contact brachytherapy and immune checkpoint inhibitors in advanced melanoma: first reported case series. [PDF]

Rep Pract Oncol Radiother
Chyrek AJ, Galus Ł, Mackiewicz J, Kluska A, Burchardt WM, Chicheł A.   +5 more
europepmc   +1 more source

Characterization of differentially expressed genes during progression of human cutaneous melanoma

, 1998
Winfried G.J. Degen
openalex   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source