Results 271 to 280 of about 869,771 (326)

The Interplay between the Gut and Ketogenic Diets in Health and Disease

Advanced Science, EarlyView.
This review synthesizes current knowledge on the interaction between ketogenic diets and the gut, covering gut physiology, intestinal immunity, and the gut microbiome. It explores innovative methods for tailoring the diet to maximize benefits while reducing side effects. Emphasis is placed on gut‐mediated mechanisms as a critical interface between diet
Chunlong Mu, Jong M. Rho, Jane Shearer
wiley   +1 more source

Systematic identification of lincRNA-derived immunogenic peptides in melanoma. [PDF]

Oncoimmunology
Dupré E, Guiho A, Beauvais T, Labous L, Cardon T, Bertolotto C, Khammari A, Quéreux G, Salzet M, Labarrière N, Rabu C, Lang F.   +11 more
europepmc   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

Advanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen, Xue‐Fei Tian, Teng Yang, Yu‐Jie Dai, Da‐Yuan Chen, Hong‐Bo Chen, Takaya Shimura, Xin‐Fang Li, Chu‐Lin Sha, Qing Ji, Jun Cao, Mei‐Yu Fang, Jin‐Biao Shang, Jian‐Min Fang, Ye Lu, Wei‐Hui Zheng, Peng Guo, Wei‐Hong Tan   +17 more
wiley   +1 more source

Correction: Radiotherapy has a survival advantage over surgery in patients with choroidal melanoma: a retrospective cohort study of 6,871 patients. [PDF]

Front Surg
Wu Y, Shi L, Ye Z, Zhou Y, Wang F, Zhang Y.   +5 more
europepmc   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion. [PDF]

Cell Death Dis
Wang Y, Liu K, Zhang Y, Novak D, Federico A, Xu C, Horschitz S, Vierthaler M, Sun Q, Wang N, Poelchen J, Steinfass T, Hüser L, Mall M, Umansky V, Utikal J.   +15 more
europepmc   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source