Results 191 to 200 of about 8,552 (232)
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In silico modeling of in situ fluidized bed melt granulation
International Journal of Pharmaceutics, 2014Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response surface methodology and artificial neural networks for optimizing in situ fluidized bed melt granulation and to compare them with ...
Ivana Aleksic +2 more
exaly +5 more sources
Effect of the melt granulation technique on the dissolution characteristics of griseofulvin
International Journal of Pharmaceutics, 2007This work describes a melt granulation technique to improve the dissolution characteristics of a poorly water-soluble drug, griseofulvin. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable binder.
Dong Yang
exaly +3 more sources
Pharmaceutical Development and Technology, 2007
The objective of the study was to evaluate the effect of formulation factors, such as type of drug and particulate properties of a drug, and processing variables, i.e. jacket temperature, impeller speed, and scale, on granulation kinetics the of hot-melt granulation (HMG) process.
A Waseem Malick +2 more
exaly +3 more sources
The objective of the study was to evaluate the effect of formulation factors, such as type of drug and particulate properties of a drug, and processing variables, i.e. jacket temperature, impeller speed, and scale, on granulation kinetics the of hot-melt granulation (HMG) process.
A Waseem Malick +2 more
exaly +3 more sources
Drug Development and Industrial Pharmacy, 2002
The objective of this study was to investigate the properties of granules and tablets prepared by a novel Fluidized Hot-Melt Granulation (FHMG) technique. Macrogol 6000 (polyethylene glycol 6000, PEG 6000), macrogol 20000 (polyethylene glycol 20000, PEG 20000), and glyceryl monostearate (GMS) were used as binders with different levels of viscosity and ...
Motonori, Kidokoro +4 more
exaly +3 more sources
The objective of this study was to investigate the properties of granules and tablets prepared by a novel Fluidized Hot-Melt Granulation (FHMG) technique. Macrogol 6000 (polyethylene glycol 6000, PEG 6000), macrogol 20000 (polyethylene glycol 20000, PEG 20000), and glyceryl monostearate (GMS) were used as binders with different levels of viscosity and ...
Motonori, Kidokoro +4 more
exaly +3 more sources
Alternative Granulation Technique: Melt Granulation
Drug Development and Industrial Pharmacy, 1996AbstractA melt granulation process has been investigated (1, 2) which efficiently agglomerates pharmaceutical powders for use in both immediate- and sustained-release solid dosage forms. The process utilizes materials that are effective as granulating fluids when they are in the molten state.
Alan Royce +3 more
openaire +1 more source
Preparation and evaluation of granules with pH-dependent release by melt granulation
International Journal of Pharmaceutics, 2012This study had two objectives: (1) to prepare, by melt granulation in a high-shear mixer, granules containing acetaminophen (APAP) as a model drug and aminoalkyl methacrylate copolymer E (AMCE) as a pH-sensitive polymer that readily dissolves at pH values lower than 5, and (2) to investigate the effects of AMCE loading (5-15%) on granule properties and
Kai, Shiino +3 more
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Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation
International Journal of Pharmaceutics, 2020Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation time varied).
Kristina E, Steffens +4 more
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MELT GRANULATION: AN ALTERNATIVE TO TRADITIONAL GRANULATION TECHNIQUES
INDIAN DRUGS, 2013Melt granulation is a size enlargement process in which the addition of a binder that melts or softens at relatively low temperatures (about 60o C) is used to achieve agglomeration of solid particles in the formulation. The process utilizes materials that are effective as granulating agents when they are in the softened or molten state.
U.S Desai +3 more
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Preparation of Essential Oils Loaded Granule by Melt Granulation
Drug Development and Industrial Pharmacy, 1994AbstractA comparative study on three granulation methods; melt granulation, fluidized bed granulation and wet granulation was performed to fabricate an essential oils loaded granule. The granule properties such as particle size distribution and the loading efficiency of anethole from fennel and cinnamaldehyde from cinnamon showed that the melt ...
Kenji Ukita, Toshio Murakami
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Kinetics of the Washing of Granules in the Melt
Theoretical Foundations of Chemical Engineering, 2001The mechanism and rate of the melt extraction of eutectic-forming impurities from granules of organic substances are considered. A diffusion model is suggested for this process, and kinetic relationships taking into account the relative closed porosity are derived for calculating the purification efficiency for granules of various shapes and sizes. The
S. K. Myasnikov +2 more
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