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International Journal of Pharmaceutics, 2023
In the pharmaceutical industry, innovative continuous manufacturing technologies such as twin-screw melt granulation (TSMG) are gaining more and more interest to process challenging formulations. To enable the implementation of TSMG, more elucidation of the process is required and this study provides a better understanding of the granule formation ...
S. Van de Steene +5 more
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In the pharmaceutical industry, innovative continuous manufacturing technologies such as twin-screw melt granulation (TSMG) are gaining more and more interest to process challenging formulations. To enable the implementation of TSMG, more elucidation of the process is required and this study provides a better understanding of the granule formation ...
S. Van de Steene +5 more
openaire +2 more sources
Melting a granulated chemically activated batch
Glass and Ceramics, 1986This paper investigates the results of preparative chemical activation and comminution of glass feedstocks prior to their melting in a furnace and also assesses the effects of this treatment on the productivity and energy efficiency of the furnace.
N. A. Mamina +3 more
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The study of salt melt granulation process
AIP Conference Proceedings, 2017The numerical simulation method was used to determine the distribution of the cooling air velocities in the granulator volume, the change in the layer temperature during the granulation process, and also the study of the efficiency of heat transfer from the salt melt layer to air.The numerical simulation method was used to determine the distribution of
Ksenia V. Kuznetsova +3 more
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Characteristics of piroxicam granules prepared by fluidized bed hot melt granulation
Advanced Powder Technology, 2018Abstract The aim of this study was to investigate the granulation of piroxicam by fluidized bed hot melt method using polyethylene glycol 4000 as the hydrophilic carrier and spray dried lactose as the fluidizing substrate. The effects of the spray nozzle air flow rate, axial position of the spray nozzle and load of fluidizing substrate on granules ...
Marília M.S. Vieira +2 more
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Particulate Science and Technology, 2015
The purpose of this research was to develop and optimize a sustained-release multiple unit floating system of a highly water-soluble drug, Acyclovir, using Gelucire 43/01 as lipid carrier and ethyl cellulose (EC) and methyl cellulose (MC) as release rate modifiers.
Ravindra S. Thakare, Sanjay B. Patil
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The purpose of this research was to develop and optimize a sustained-release multiple unit floating system of a highly water-soluble drug, Acyclovir, using Gelucire 43/01 as lipid carrier and ethyl cellulose (EC) and methyl cellulose (MC) as release rate modifiers.
Ravindra S. Thakare, Sanjay B. Patil
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Fast-melting tablets based on highly plastic granules
Journal of Controlled Release, 2005Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder.
Yourong, Fu +2 more
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European Journal of Pharmaceutics and Biopharmaceutics, 2016
The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles ...
Tinne, Monteyne +4 more
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The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles ...
Tinne, Monteyne +4 more
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Formation of hollow core granules by fluid bed in situ melt granulation: Modelling and experiments
International Journal of Pharmaceutics, 2006Granules with a characteristic core-shell internal structure have been formed by in situ melt fluid-bed granulation, using d-mannitol primary solid particles and poly-ethylene glycol (PEG-6000) binder. The effect of binder particle size and binder/solids ratio on granule size distribution was systematically investigated. The mean granule size was found
Mansoor A, Ansari, Frantisek, Stepanek
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Preparing of aspirin sustained-release granules by hot-melt granulation and micro-crystal coating
Drug Development and Industrial Pharmacy, 2019In this work, aspirin (ASP) sustained granules were prepared using micro-crystal coating and hot-melt granulation, respectively. In the process of micro-crystal coating, PVP was used to form the isolation layer and then coated with either Eudragit RS/RL30D or ethyl cellulose (EC) as sustained-release layers to prepare sustained granules (the granules ...
Ran, Li +5 more
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Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
International Journal of PharmaceuticsTwin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive research conducted on the impact of screw geometry in melt compounding, there is not enough literature for TSMG.
Adwait Pradhan +7 more
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