Results 61 to 70 of about 744,006 (340)

Influence of the nature of confinement on the melting of Wigner molecules in quantum dots

, 2015
We analyze the quantum melting of two-dimensional Wigner molecules (WM) in confined geometries with distinct symmetries and compare it with corresponding thermal melting.
Bhattacharya, Dyuti, Bonitz, M., Filinov, A. V., Ghosal, Amit   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Observing Picomolar Protein Unfolding Using Resonance Light Scattering

Biomolecules
We here present a novel and sensitive methodology for determining the melting point (MP) of Bovine Serum Albumin (BSA) from micromolar to picomolar concentration levels under label-free conditions. At 1 pM we could model the melting with a sharp Gaussian.
Alain Bolaño Alvarez, Kristian Bakke Arvesen, Kasper Fjellhaugen Hjuler, Peter Bjerring, Steffen B. Petersen   +4 more
doaj   +1 more source

Melting and nonmelting of solid surfaces and nanosystems

, 2005
We present an extensive but concise review of our present understanding, largely based on theory and simulation work from our group, on the equilibrium behavior of solid surfaces and nanosystems close to the bulk melting point.
Ercolessi, F., Tartaglino, U., Tosatti, E., Zykova-Timan, T.   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DYNAMICAL NANOSRUCTURING OF NaCl PREMELTING PHASES

Конденсированные среды и межфазные границы, 2018
Complex investigation of NaCl premelting phases dynamical structuring have been carry out in different kinetic conditions. The transient states near the melting point are fl uctuating, nonequilibrium processes, which are accompanied by dissipative states
Ekaterina S. Mashkina, Konstantin A. Barkov   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

ANALYSIS OF THE STABILTY OF DYNAMIC NANOSTRUCTURED PHASES NEAR THE MELTING POINT FOR COPPER

Конденсированные среды и межфазные границы, 2017
Transition of a system to a non-equilibrium state is closely associated with the loss of the system’s stability. When considering the behaviour of matter near melting points, non-equilibrium physics puts focus on the properties of matter in the ...
Mashkina Ekaterina S.
doaj   +1 more source

Optimization of Natural Lipstick Formulation Based on Pitaya (Hylocereus polyrhizus) Seed Oil Using D-Optimal Mixture Experimental Design

Molecules, 2014
The D-optimal mixture experimental design was employed to optimize the melting point of natural lipstick based on pitaya (Hylocereus polyrhizus) seed oil. The influence of the main lipstick components—pitaya seed oil (10%–25% w/w), virgin coconut oil (25%
Norsuhaili Kamairudin, Siti Salwa Abd Gani, Hamid Reza Fard Masoumi, Puziah Hashim   +3 more
doaj   +1 more source