Results 41 to 50 of about 126,334 (245)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Journal of Aesthetics & Culture, 2019 This article analyses the production of prospective memories in the 2012 BBC documentary A Jubilee Tribute to The Queen by The Prince of Wales. The contemporary British monarchy relies heavily on memory products in order to connect to their subjects and ...
Christina Jordan
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
L'Evolucionisme a les memòries de la Reial Acadèmia de Ciències i Arts de Barcelona a finals del segle XIX [PDF]
, 2010 A finals del segle XIX, després de la publicació de The origin of species per part de Charles Darwin, hi va haver fortes controvèrsies entre partidaris i detractors de l'evolucionisme.
Sucarrats i Riera, Raimon
core
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
La integració de les tecnologies de la llengua en el flux de treball del Servei Lingüístic de la UOC [PDF]
, 2009 L’article aborda les tecnologies de la llengua que es fan servir al Servei Lingüístic de la UOC i de quina manera s’integren en cadascun dels diferents processos productius del Servei.
Corral, Alba +2 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Episodic memories and their relevance for psychoactive drug use and addiction
Frontiers in Behavioral Neuroscience, 2013 The majority of adult people in western societies regularly consume psychoactive drugs. While this consumption is integrated in everyday life activities and controlled in most consumers, it may escalate and result in drug addiction. Non-addicted drug use
Christian P. Müller
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source