Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Sales Market Regulations for Agricultural Land in EU Member States and Candidate Countries [PDF]
All agricultural markets are subjected to institutional regulations that – in one way or another –affect the functioning of these markets, and this is no different for the agricultural land market in the EU.
Ciaian, Pavel, +4 more
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STATE VERSUS STATE: WHO APPLIES BETTER EU LAW? [PDF]
Each Member State is responsible for the implementation of EU Law within its own legal system. Non-compliance means failure by a Member State to fulfil its obligations under EU Law.
Ioana Mihaela DIMITRIU
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
EU member states and the European neighbourhood policy
The EU’s neighbourhood policy remains a conundrum. With a multitude of objectives, the project was inspired by the goal of fostering stability, security and prosperity in a shared neighbourhood.
Hadfield, A.
core
Researchers and policy‐makers accept that implementation decisively influences the effectiveness of European (EU) environmental policy. Member states follow a variety of compliance (or non‐compliance) paths.
Bültmann, A. +3 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
New Member States' Trading Potential Following EMU Accession: A Gravity Approach [PDF]
The purpose of this paper is to look at implications of the EMU accession on international trade flows of the new member states with members of the enlarged EU.
Maryla Maliszewska
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The First EU Social Partner Agreement in Practice: Parental Leave in the 15 Member States. IHS Political Science Series: 2004, No. 96 [PDF]
In this paper, we analyze the impact of one specific EU social policy measure, the Parental Leave Directive. This Directive is based on the first Euro-collective agreement, concluded in November 1995 by the ETUC, UNICE and CEEP.
Treib, Oliver, Falkner, Gerda.
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