Results 31 to 40 of about 671,733 (267)

Resolving the renal microenvironment: a 5-plex immunofluorescence workflow to quantify B-lineage cells in FFPE lupus nephritis biopsies

Frontiers in Immunology
Accurate identification and spatial enumeration of B lineage cells in formalin-fixed, paraffin-embedded (FFPE) lupus nephritis (LN) kidney tissue is critical for understanding disease pathogenesis and CD20-directed therapeutic responses.
Caleb Chan, Patrick S. Chang, Sreedevi Chalasani, Janet Tao, Harini Raghu, Cary D. Austin   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

INVESTIGATING THE DETERMINANTS OF LONG-RUN SOVEREIGN RATING [PDF]

Financial Studies, 2014
The significance of sovereign rating for local and international investors is essential because in recent period many countries had problems concerning the payment of public loans.
Emilian - Constantin MIRICESCU
doaj  

Common foreign and security policy and European security and defence policy after the Lisbon Treaty – Old problems solved?

Croatian Yearbook of European Law and Policy, 2009
In its aim to become a global security actor, the EU is increasingly undertaking civilian and military crisis missions all over the world. These missions are based on the European security and defence policy (ESDP) which forms an integral part of its ...
Julia Schmidt
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Regulation of screening of foreign direct investments in the European Union: Key features and reaches [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu
The subject of analysis in this paper are the key features of the regulatory concept of Foreign Direct Investment Screening established by Regulation 2019/452. The rules of the said Regulation are directed towards three main pillars, which simultaneously
Divljak Drago Lj.
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Secessions from EU Member States: The Imperative of Union's Neutrality

European Papers, 2016
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(1), 67-92 | Article | (Table of Contents) I. Introduction. - II. A word about the artificiality of secessions' exceptionalism. - III.
Dimitry Kochenov, Martijn van den Brink
doaj   +1 more source

ECO-EFFICIENCY IN AGRICULTURE OF EUROPEAN UNION MEMBER STATES [PDF]

Annals of the Polish Association of Agricultural and Agribusiness Economists, 2018
The objective of the paper is to estimate efficiency and eco-efficiency of agriculture in 24 EUMember States from 2006 to 2015. In the study, a panel of yearly aggregated data [Eurostat 2018] of the totalvalue of agricultural goods output (AGO), labour ...
Ľubica Bartová, Peter Fendel, Eva Matejková   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source